Combined Treatment with Two Water Extracts of Eleutherococcus senticosus Leaf and Rhizome of Drynaria fortunei Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind Study in Healthy Adults.

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  • Additional Information
    • Source:
      Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI Publishing
    • Subject Terms:
    • Abstract:
      We previously found that the water extract of Eleutherococcus senticosus leaves (ES extract) enhanced cognitive function in normal mice. Our study also revealed that the water extract of rhizomes of Drynaria fortunei (DR extract) enhanced memory function in Alzheimer's disease model mice. In addition, our previous experiments suggested that a combined treatment of ES and DR extracts synergistically improved memory and anti-stress response in mice. Although those two botanical extracts are expected to be beneficial for neuropsychological function, no clinical data has ever been reported. Therefore, we performed a placebo-controlled, randomized, double-blind study to evaluate cognitive enhancement and anti-stress effects by the intake of a combined extract in healthy volunteers. The intake period was 12 weeks. The Japanese version of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) test was used for neurocognitive assessment. The combined treatment of ES and DR extracts significantly increased the figure recall subscore of RBANS ( p = 0.045) in an intergroup comparison. Potentiation of language domain (( p = 0.040), semantic fluency ( p = 0.021) and figure recall ( p = 0.052) was shown by the extracts (in intragroup comparison). In anti-stress response, the anxiety/uncertainly score was improved by the extract in an intragroup comparison ( p = 0.022). No adverse effects were observed. The combined treatment of ES and DR extracts appear to safely enhance a part of cognitive function in healthy adults.
      Competing Interests: The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
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    • Grant Information:
      no number R&D grant from The Hokuriku Industrial Advancement Center; no number a grant-in-aid for the Cooperative Research Project from the Institute of Natural Medicine at the University of Toyama in 2014 and 2015; no number the Discretionary Funds of the President of the University of Toyama
    • Contributed Indexing:
      Keywords: Drynaria fortunei rhozomes; Eleutherococcus senticosus leaves; Healthy subject; anti-stress; cognitive function
    • Accession Number:
      0 (Nootropic Agents)
      0 (Plant Extracts)
      0 (Solvents)
      059QF0KO0R (Water)
    • Publication Date:
      Date Created: 20200126 Date Completed: 20201127 Latest Revision: 20201127
    • Publication Date:
      20221213
    • Accession Number:
      PMC7070741
    • Accession Number:
      10.3390/nu12020303
    • Accession Number:
      31979283