Occurrence and Antimicrobial Resistance Profiles of Campylobacter jejuni , Campylobacter coli , and Campylobacter upsaliensis in Beef Cattle on Cow-Calf Operations in South Africa.

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  • Additional Information
    • Source:
      Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101120121 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-7125 (Electronic) Linking ISSN: 15353141 NLM ISO Abbreviation: Foodborne Pathog Dis Subsets: MEDLINE
    • Publication Information:
      Original Publication: Larchmont, NY : Mary Ann Liebert, Inc., c2004-
    • Subject Terms:
      Drug Resistance, Bacterial*; Campylobacter Infections/*microbiology ; Campylobacter coli/*drug effects ; Campylobacter jejuni/*drug effects ; Campylobacter upsaliensis/*drug effects; Animals ; Anti-Bacterial Agents/pharmacology ; Campylobacter Infections/epidemiology ; Campylobacter Infections/veterinary ; Campylobacter coli/isolation & purification ; Campylobacter jejuni/isolation & purification ; Campylobacter upsaliensis/isolation & purification ; Cattle ; Feces/microbiology ; Microbial Sensitivity Tests ; Rectum/microbiology ; South Africa/epidemiology
    • Abstract:
      This study investigated occurrence and antimicrobial resistance profiles of Campylobacter spp. isolates in beef cattle on five cow-calf operations in South Africa. A total of 537 fecal samples from adult beef cattle ( n  = 435) and rectal swabs from calves ( n  = 102) were screened for Campylobacter jejuni , Campylobacter coli , and Campylobacter upsaliensis by culture and polymerase chain reaction. Furthermore, 86 Campylobacter spp. isolates including 46 C. jejuni , 24 C. coli , and 16 C. upsaliensis were tested for antimicrobial resistance against a panel of 9 antimicrobials. Overall, Campylobacter spp. was detected in 29.7% of cattle. Among the 158 Campylobacter spp.-positive cattle, 61.8% carried C. jejuni , 25% carried C. coli , and 10% carried C. upsaliensis . Five animals (3.1%) had mixed infections: three cows carried C. jejuni and C. coli concurrently, one cow had both C. jejuni and C. upsaliensis , and one cow harbored C. coli and C. upsaliensis . Antimicrobial resistance profiling among 86 Campylobacter spp. isolates revealed that 52.3% of the isolates were resistant to one or more antimicrobials. Antimicrobial resistance was observed in 46.7% of C. jejuni isolates, 35.6% of C. coli , and 17.8% of C. upsaliensis . Thirty-six percent of isolates were resistant to clindamycin, 19.7% to nalidixic acid, 18.6% to tetracycline, and 17.4% to erythromycin. Lower resistance rates were recorded for azithromycin (8.1%), florfenicol (3.4%), gentamicin (4.8%), and telithromycin and ciprofloxacin (5.8%). Multidrug resistance (MDR) was observed in 32.5% of isolates. Significantly higher levels of MDR were detected among C. jejuni (36.9%) and C. coli (33.3%) isolates in comparison to C. upsaliensis (18.7%). Two main multiresistance patterns were detected: nalidixic acid/clindamycin (17.8%) and tetracycline/clindamycin (14.2%). To the best of our knowledge, this is the first study which has shown that beef cattle on cow-calf operations in South Africa constitute an important reservoir and a potential source of clinically relevant and antimicrobial resistant Campylobacter spp. strains.
    • Contributed Indexing:
      Keywords: Campylobacter spp.; South Africa; antimicrobial resistance; beef cattle
    • Accession Number:
      0 (Anti-Bacterial Agents)
    • Publication Date:
      Date Created: 20200115 Date Completed: 20210806 Latest Revision: 20210806
    • Publication Date:
      20221213
    • Accession Number:
      10.1089/fpd.2019.2703
    • Accession Number:
      31934792