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HDL cholesterol is an independent predictor of β-cell function decline and incident type 2 diabetes: A longitudinal study.
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- Author(s): Fiorentino TV;Fiorentino TV; Succurro E; Succurro E; Marini MA; Marini MA; Pedace E; Pedace E; Andreozzi F; Andreozzi F; Perticone M; Perticone M; Sciacqua A; Sciacqua A; Perticone F; Perticone F; Sesti G; Sesti G; Sesti G
- Source:
Diabetes/metabolism research and reviews [Diabetes Metab Res Rev] 2020 May; Vol. 36 (4), pp. e3289. Date of Electronic Publication: 2020 Feb 04.- Publication Type:
Journal Article; Observational Study- Language:
English - Source:
- Additional Information
- Source: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883450 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-7560 (Electronic) Linking ISSN: 15207552 NLM ISO Abbreviation: Diabetes Metab Res Rev Subsets: MEDLINE
- Publication Information: Original Publication: Oxford, England : Wiley-Blackwell, c1999-
- Subject Terms: Body Mass Index* ; Insulin Resistance*; Biomarkers/*blood ; Cholesterol, HDL/*blood ; Diabetes Mellitus, Type 2/*epidemiology ; Insulin-Secreting Cells/*pathology; Blood Glucose/analysis ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/pathology ; Female ; Follow-Up Studies ; Humans ; Insulin-Secreting Cells/metabolism ; Italy/epidemiology ; Longitudinal Studies ; Male ; Middle Aged ; Prognosis ; Waist Circumference
- Abstract: Background: Experimental evidence indicates that high-density lipoprotein (HDL) may stimulate glucose uptake and improve β-cell function. The aim of this study was to evaluate whether lower levels of HDL may affect the risk to develop type 2 diabetes.
Methods: Incident rate of type 2 diabetes and changes in insulin sensitivity and β-cell function over 5.5-year follow-up were examined in 670 non-diabetic subjects stratified in tertiles according to basal HDL levels.
Results: As compared to the highest tertile of HDL, individuals with lower levels of HDL have an increased risk to develop type 2 diabetes independently from several cardiometabolic risk factors (odds ratio: 2.88, 95% confidence interval: 1.05-7.91), and exhibited a greater deterioration of β-cell function, estimated by the disposition index, over 5.5-year follow-up. Conversely, changes in Matsuda index of insulin sensitivity over the follow-up were not significantly different amongst the three HDL groups. In a multivariable regression analysis model including age, sex, waist circumference, triglycerides, total cholesterol, C-reactive protein, fasting and 2-hour post-load glucose, family history of type 2 diabetes and smoking habit, HDL concentration at baseline was an independent predictor of β-cell function decline over the follow-up (β = .30, P = .0001). Mediation analysis showed that the association between lower HDL levels at baseline and increased risk of incident diabetes was mediated by β-cell function deterioration during the follow-up (t = -3.32, P = .001).
Conclusions: Subjects with lower levels of HDL have an increased risk to develop type 2 diabetes likely due to a greater β-cell function decline over time.
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- Accession Number: 0 (Biomarkers)
0 (Blood Glucose)
0 (Cholesterol, HDL) - Publication Date: Date Created: 20200111 Date Completed: 20210708 Latest Revision: 20210708
- Publication Date: 20221213
- Accession Number: 10.1002/dmrr.3289
- Accession Number: 31922637
- Source:
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