Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism.

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  • Additional Information
    • Source:
      Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 0121103 Publication Model: Print Cited Medium: Print ISSN: 0065-2598 (Print) Linking ISSN: 00652598 NLM ISO Abbreviation: Adv Exp Med Biol Subsets: MEDLINE
    • Publication Information:
      Publication: 1998- : New York : Kluwer Academic/Plenum Publishers
      Original Publication: New York, Plenum Press.
    • Subject Terms:
      Cerebrovascular Circulation*/physiology ; Cerebrum*/metabolism ; Hypothermia* ; Models, Biological*; Animals ; Animals, Newborn ; Computer Simulation ; Humans ; Hypothermia, Induced ; Hypoxia-Ischemia, Brain ; Swine
    • Abstract:
      Hypoxic ischemic encephalopathy (HIE) is a significant cause of death and neurological disability in newborns. Therapeutic hypothermia at 33.5 °C is one of the most common treatments in HIE and generally improves outcome; however 45-55% of injuries still result in death or severe neurodevelopmental disability. We have developed a systems biology model of cerebral oxygen transport and metabolism to model the impact of hypothermia on the piglet brain (the neonatal preclinical animal model) tissue physiology. This computational model is an extension of the BrainSignals model of the adult brain. The model predicts that during hypothermia there is a 5.1% decrease in cerebral metabolism, 1.1% decrease in blood flow and 2.3% increase in cerebral tissue oxygenation saturation. The model can be used to simulate effects of hypothermia on the brain and to help interpret bedside recordings.
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    • Contributed Indexing:
      Keywords: Broadband NIRS; Hypothermia; Systems biology
    • Publication Date:
      Date Created: 20200102 Date Completed: 20200108 Latest Revision: 20221130
    • Publication Date:
      20221213
    • Accession Number:
      PMC9703273
    • Accession Number:
      10.1007/978-3-030-34461-0_38
    • Accession Number:
      31893424