Efficacy of VERYL® in the treatment of cattle naturally infected with gastro-intestinal nematodes in Kenya.

Publisher: Springer Country of Publication: United States NLM ID: 1277355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7438 (Electronic) Linking ISSN: 00494747 NLM ISO Abbreviation: Trop Anim Health Prod Subsets: MEDLINE

Publication: 2005- : Heidelberg : Springer
Original Publication: Edinburgh, Livingstone.

Anthelmintics/*therapeutic use ; Cattle Diseases/*drug therapy ; Diminazene/*analogs & derivatives ; Levamisole/*therapeutic use ; Nematode Infections/*veterinary; Animals ; Cattle ; Diminazene/therapeutic use ; Feces/parasitology ; Haemonchus/isolation & purification ; Kenya ; Nematode Infections/drug therapy ; Parasite Egg Count/veterinary ; Random Allocation ; Trichostrongylus/isolation & purification

Co-infections caused by trypanosomes and gastro-intestinal nematodes (GINs) compromise cattle productivity and their control requires a holistic approach. The effectiveness of trypanocides and anthelmintics is compromised by increasing resistance. Use of combined chemotherapeutic products for synergy, mainly practiced in human medicine, is gaining importance in livestock. A trial to evaluate efficacy of VERYL®, containing diminazene diaceturate (3.5 mg/kg body weight) and levamisole chloride (5 mg/kg body weight) for the control of GINs in cattle, was conducted at KALRO-VSRI Muguga, Kenya, between June and August 2016. Thirty-eight cattle aged between 6 and 12 months, naturally infected with GINs, were randomly allocated into two groups; a treatment group received VERYL® intra-muscularly at 10 mL/100 kg bwt and a control group which received Veriben® (Diminazene aceturate) at 3.5 mg/kg bwt. Faecal egg counts (FECs), coproculture, packed cell volume (PCV) and local tolerance at the injection site were measured during the study. FECs were comparable between the treatment and control groups at day 0. However, treatment of cattle with VERYL significantly (p < 0.001) reduced FECs by day 7 and sustained to day 21 post-treatment. Coproculture results for the treatment and control groups revealed presence of Haemonchus, Cooperia, Ostertagia, Trichostrongylus and Oesophagostomum species. Cattle treated with VERYL® had a significant (p < 0.05) reduction in larval recoveries compared to the control group. VERYL® had minimal adverse effects which cleared after a short while and is thus recommended for controlling GINs in cattle.

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CLT/C753/1514 Ceva Sante Animale

Keywords: Efficacy; Faecal egg counts; Helminths

0 (Anthelmintics)
2880D3468G (Levamisole)
JI8SAD85NO (diminazene aceturate)
Y5G36EEA5Z (Diminazene)

Date Created: 20191223 Date Completed: 20201112 Latest Revision: 20210203

20221213

10.1007/s11250-019-02179-4

31865537