Electron radiotherapy (IOERT) for applications outside of the breast: Dosimetry and influence of tissue inhomogeneities.

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  • Additional Information
    • Source:
      Publisher: Istituti Editoriali e Poligrafici Internazionali Country of Publication: Italy NLM ID: 9302888 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1724-191X (Electronic) Linking ISSN: 11201797 NLM ISO Abbreviation: Phys Med Subsets: MEDLINE
    • Publication Information:
      Publication: Pisa : Istituti Editoriali e Poligrafici Internazionali
      Original Publication: Lugano, Switzerland : Giardini editori S.A.,
    • Subject Terms:
      Electrons*/therapeutic use ; Neoplasms*/diagnostic imaging ; Neoplasms*/radiotherapy ; Phantoms, Imaging* ; Radiometry*/methods ; Radiotherapy*/methods; Humans ; Bone and Bones/diagnostic imaging ; Film Dosimetry ; Intraoperative Period ; Particle Accelerators ; Reproducibility of Results ; Semiconductors ; Silicon/chemistry ; Thermoluminescent Dosimetry
    • Abstract:
      Purpose: The purpose of study is to investigate the dosimetry of electron intraoperative radiotherapy (IOERT) of the Intraop Mobetron 2000 mobile LINAC in treatments outside of the breast. After commissioning and external validation of dosimetry, we report in vivo results of measurements for treatments outside the breast in a large patient cohort, and investigate if the presence of inhomogeneities can affect in vivo measurements.
      Methods and Materials: Applicator factors and profile curves were measured with a stereotactic diode. The applicators factors of the 6 cm flat and beveled applicators were also confirmed with radiochromic films, parallel-plate ion chamber and by an external audit performed with ThermoLuminescent Dosimeters (TLDs). The influence of bone on dose was investigated by using radiochromic films attached to an insert equivalent to cortical bone, immersed in the water phantom. In vivo dosimetry was performed on 126 patients treated with IOERT using metal oxide-silicon semiconductor field effect transistors (MOSFETs) placed on the tumor bed.
      Results: Relatively small differences were found among different detectors for measurements of applicator factors. In the external audit, the agreement with the TLD was mostly within ±0.2%. The largest increase of dose due to the presence of cortical bone insert was +6.0% with energy 12 MeV and 3 cm applicator. On average, in vivo dose was significantly (+3.1%) larger than prescribed dose.
      Conclusion: IOERT in applications outside the breast results in low discrepancies between in vivo and prescribed doses, which can be also explained with the presence of tissue inhomogeneity.
      (Copyright © 2019 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Dosimetry; Electron therapy; Intra-operative; Radiation therapy; Radiochromic film
    • Accession Number:
      Z4152N8IUI (Silicon)
    • Publication Date:
      Date Created: 20191217 Date Completed: 20201026 Latest Revision: 20240614
    • Publication Date:
      20240615
    • Accession Number:
      10.1016/j.ejmp.2019.12.003
    • Accession Number:
      31841774