Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head.

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  • Additional Information
    • Source:
      Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 8604127 Publication Model: eCollection Cited Medium: Internet ISSN: 1875-8630 (Electronic) Linking ISSN: 02780240 NLM ISO Abbreviation: Dis Markers Subsets: MEDLINE
    • Publication Information:
      Publication: 2015- : New York, NY : Hindawi Pub. Corp.
      Original Publication: Chichester ; New York : Wiley, c1983-
    • Subject Terms:
      Gene Expression Profiling* ; Gene Expression Regulation, Neoplastic*; Biomarkers/*analysis ; Femur Head/*metabolism ; Osteonecrosis/*genetics ; RNA, Circular/*genetics ; Steroids/*adverse effects; Case-Control Studies ; Femur Head/drug effects ; Femur Head/pathology ; High-Throughput Nucleotide Sequencing ; Humans ; Osteonecrosis/chemically induced ; Osteonecrosis/pathology ; Prognosis
    • Abstract:
      Background: A growing number of studies have suggested that circular RNAs (circRNAs) serve as potential diagnostic biomarkers in many diseases. However, the role of circRNAs in steroid-induced osteonecrosis of the femoral head (SONFH) has not been reported.
      Methods: Secondary sequencing was performed to profile circRNA expression in peripheral blood samples from three SONFH patients and three healthy individuals. We confirmed our preliminary findings by qRT-PCR. Bioinformatics analysis was conducted to predict their functions.
      Results: The result showed 345 dysregulated circRNAs. qRT-PCR of eight selected circRNAs preliminarily confirmed the results, which were consistent with RNA sequencing. Bioinformatics analyses were performed to predict the functions of circRNAs to target the genes of miRNAs and the networks of circRNA-miRNA-mRNA interactions.
      Conclusions: This study provides a new and fundamental circRNA profile of SONFH and a theoretical basis for further studies on the functions of circRNAs in SONFH.
      Competing Interests: The authors declare they have no competing interests.
      (Copyright © 2019 Zhongxin Zhu et al.)
    • References:
      Best Pract Res Clin Endocrinol Metab. 2015 Aug;29(4):545-56. (PMID: 26303082)
      Biomed Pharmacother. 2019 Mar;111:198-208. (PMID: 30583227)
      Joint Bone Spine. 2013 Jan;80(1):70-6. (PMID: 22503166)
      Mol Immunol. 2017 Oct;90:264-272. (PMID: 28846924)
      J Res Med Sci. 2017 Feb 16;22:15. (PMID: 28458706)
      Int Orthop. 2019 May;43(5):1083-1087. (PMID: 29876626)
      Mod Rheumatol. 2015 Mar;25(2):278-81. (PMID: 25036228)
      BMC Bioinformatics. 2017 Jul 21;18(1):350. (PMID: 28732468)
      Diab Vasc Dis Res. 2017 Nov;14(6):510-515. (PMID: 28777011)
      Biomaterials. 2016 Mar;81:84-92. (PMID: 26724456)
      Cell Res. 2015 Aug;25(8):981-4. (PMID: 26138677)
      Nucleic Acids Res. 2019 Jan 8;47(D1):D590-D595. (PMID: 30321428)
      EBioMedicine. 2018 Jan;27:18-26. (PMID: 29248507)
      Int J Mol Med. 2018 Dec;42(6):3256-3268. (PMID: 30272257)
      Clin Cases Miner Bone Metab. 2015 Sep-Dec;12(3):257-9. (PMID: 26811707)
      Biochim Biophys Acta. 2016 Nov;1860(11 Pt B):2619-26. (PMID: 27208425)
      Pathol Res Pract. 2005;200(11-12):807-11. (PMID: 15792124)
      J Cell Physiol. 2019 Jan 17;:null. (PMID: 30656680)
      Nat Methods. 2011 Sep 04;8(10):841-3. (PMID: 21892151)
      Clin Exp Immunol. 2018 Oct;194(1):118-124. (PMID: 30216431)
      J Biol Regul Homeost Agents. 2018 Nov-Dec;32(6 Suppl. 1):173-179. (PMID: 30644299)
      J Am Acad Orthop Surg. 2015 Feb;23(2):69-70. (PMID: 25624358)
      Cell Physiol Biochem. 2016;39(6):2239-2248. (PMID: 27832630)
      Mol Med Rep. 2015 Nov;12(5):7447-54. (PMID: 26459755)
      J Int Med Res. 2018 Jun;46(6):2141-2148. (PMID: 28459353)
      J Biotechnol. 2016 Nov 20;238:42-51. (PMID: 27671698)
      Exp Mol Med. 2014 Jul 25;46:e107. (PMID: 25060766)
      Nucleic Acids Res. 2011 Jan;39(Database issue):D19-21. (PMID: 21062823)
      Int J Mol Med. 2015 Sep;36(3):678-84. (PMID: 26151338)
      Sci Rep. 2017 Jan 03;7:39918. (PMID: 28045102)
      PLoS One. 2015 Oct 20;10(10):e0141214. (PMID: 26485708)
      Int Orthop. 2018 Jul;42(7):1605-1614. (PMID: 29700584)
      Mol Med Rep. 2014 Dec;10(6):3118-24. (PMID: 25323050)
      Gene. 2018 Sep 10;671:103-109. (PMID: 29859289)
      Cell Prolif. 2018 Feb;51(1):null. (PMID: 29205600)
      Oncol Lett. 2016 Feb;11(2):1201-1206. (PMID: 26893719)
      EBioMedicine. 2018 Aug;34:267-274. (PMID: 30078734)
      Cell. 2019 May 2;177(4):865-880.e21. (PMID: 31031002)
      Arthritis. 2012;2012:601763. (PMID: 23243507)
      Acta Diabetol. 2017 Mar;54(3):237-245. (PMID: 27878383)
      J Bone Joint Surg Am. 2015 Oct 7;97(19):1604-27. (PMID: 26446969)
      Mol Syst Biol. 2009;5:290. (PMID: 19638971)
      Cell Physiol Biochem. 2016;39(3):1111-7. (PMID: 27562849)
      Blood. 2016 Mar 3;127(9):e1-e11. (PMID: 26660425)
      J Bone Joint Surg Br. 1985 Jan;67(1):3-9. (PMID: 3155745)
    • Accession Number:
      0 (Biomarkers)
      0 (RNA, Circular)
      0 (Steroids)
    • Publication Date:
      Date Created: 20191213 Date Completed: 20200501 Latest Revision: 20220411
    • Publication Date:
      20240628
    • Accession Number:
      PMC6885284
    • Accession Number:
      10.1155/2019/8759642
    • Accession Number:
      31827647