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Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head.
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- Author(s): Zhu Z;Zhu Z;Zhu Z; Du W; Du W; Yu H; Yu H; Yu H; Jin H; Jin H; Jin H; Tong P; Tong P; Tong P
- Source:
Disease markers [Dis Markers] 2019 Nov 15; Vol. 2019, pp. 8759642. Date of Electronic Publication: 2019 Nov 15 (Print Publication: 2019).- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 8604127 Publication Model: eCollection Cited Medium: Internet ISSN: 1875-8630 (Electronic) Linking ISSN: 02780240 NLM ISO Abbreviation: Dis Markers Subsets: MEDLINE
- Publication Information: Publication: 2015- : New York, NY : Hindawi Pub. Corp.
Original Publication: Chichester ; New York : Wiley, c1983- - Subject Terms: Gene Expression Profiling* ; Gene Expression Regulation, Neoplastic*; Biomarkers/*analysis ; Femur Head/*metabolism ; Osteonecrosis/*genetics ; RNA, Circular/*genetics ; Steroids/*adverse effects; Case-Control Studies ; Femur Head/drug effects ; Femur Head/pathology ; High-Throughput Nucleotide Sequencing ; Humans ; Osteonecrosis/chemically induced ; Osteonecrosis/pathology ; Prognosis
- Abstract: Background: A growing number of studies have suggested that circular RNAs (circRNAs) serve as potential diagnostic biomarkers in many diseases. However, the role of circRNAs in steroid-induced osteonecrosis of the femoral head (SONFH) has not been reported.
Methods: Secondary sequencing was performed to profile circRNA expression in peripheral blood samples from three SONFH patients and three healthy individuals. We confirmed our preliminary findings by qRT-PCR. Bioinformatics analysis was conducted to predict their functions.
Results: The result showed 345 dysregulated circRNAs. qRT-PCR of eight selected circRNAs preliminarily confirmed the results, which were consistent with RNA sequencing. Bioinformatics analyses were performed to predict the functions of circRNAs to target the genes of miRNAs and the networks of circRNA-miRNA-mRNA interactions.
Conclusions: This study provides a new and fundamental circRNA profile of SONFH and a theoretical basis for further studies on the functions of circRNAs in SONFH.
Competing Interests: The authors declare they have no competing interests.
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J Bone Joint Surg Br. 1985 Jan;67(1):3-9. (PMID: 3155745) - Accession Number: 0 (Biomarkers)
0 (RNA, Circular)
0 (Steroids) - Publication Date: Date Created: 20191213 Date Completed: 20200501 Latest Revision: 20220411
- Publication Date: 20240628
- Accession Number: PMC6885284
- Accession Number: 10.1155/2019/8759642
- Accession Number: 31827647
- Source:
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