Saposin-like proteins in Opisthorchis felineus and related opisthorchids.

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  • Author(s): Pirozhkova D;Pirozhkova D; Katokhin A; Katokhin A; Katokhin A
  • Source:
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2020 Mar; Vol. 78, pp. 104132. Date of Electronic Publication: 2019 Dec 02.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101084138 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1567-7257 (Electronic) Linking ISSN: 15671348 NLM ISO Abbreviation: Infect Genet Evol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam ; New York : Elsevier Science, c2001-
    • Subject Terms:
      Helminth Proteins/*genetics ; Opisthorchis/*genetics ; Saposins/*genetics; Alternative Splicing ; Animals ; Clonorchis sinensis/genetics ; Cricetinae ; Exons ; Gene Expression ; Introns ; Opisthorchis/isolation & purification ; Phylogeny ; RNA Splice Sites ; RNA, Messenger/genetics ; Reproducibility of Results ; Transcriptome
    • Abstract:
      Saposin B domain-containing or saposin-like proteins (SAPs, SAPLIPs) have been described as lipid/membrane-binding and often show antibacterial and cytolytic activity. Members of this protein family are present in phylogenetically distant organisms, pointing to their functional importance. Several SAPs are found in trematodes and some of them apparently are related to host-parasite interaction as they show cytolytic activity or immunogenicity. In the present study, we search for SAP genes of Opisthorchis felineus, Clonorchis sinensis and O. viverrini, compare and analyze their structure and expression patterns. We define three orthologous groups of SAPs in opisthorchids and suggest a unique protein motif with unknown function in one group of orthologs.
      (Copyright © 2019 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Gene expression; Opisthorchis felineus; Orthology; opisthorchids; saposin B domain
    • Accession Number:
      0 (Helminth Proteins)
      0 (RNA Splice Sites)
      0 (RNA, Messenger)
      0 (Saposins)
    • Publication Date:
      Date Created: 20191206 Date Completed: 20210219 Latest Revision: 20210219
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.meegid.2019.104132
    • Accession Number:
      31805380