Lessons learned from adenovirus (1970-2019).

Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3468 (Electronic) Linking ISSN: 00145793 NLM ISO Abbreviation: FEBS Lett Subsets: MEDLINE

Publication: Jan. 2016- : West Sussex : John Wiley & Sons Ltd.
Original Publication: Amsterdam, North-Holland on behalf of the Federation of European Biochemical Societies.

Adenoviridae/*physiology ; Genetic Vectors/*administration & dosage ; Receptors, Cell Surface/*metabolism; Adenoviridae/genetics ; Animals ; Clinical Trials as Topic ; Genetic Vectors/therapeutic use ; Humans ; Virus Attachment ; Virus Internalization

Animal viruses are well recognized for their ability to uncover fundamental cell and molecular processes, and adenovirus certainly provides a prime example. This review illustrates the lessons learned from studying adenovirus over the past five decades. We take a look back at the key studies of adenovirus structure and biophysical properties, which revealed the mechanisms of adenovirus association with antibody, cell receptor, and immune molecules that regulate infection. In addition, we discuss the critical contribution of studies of adenovirus gene expression to elucidation of fundamental reactions in pre-mRNA processing and its regulation. Other pioneering studies furnished the first examples of protein-primed initiation of DNA synthesis and viral small RNAs. As a nonenveloped virus, adenoviruses have furnished insights into the modes of virus attachment, entry, and penetration of host cells, and we discuss the diversity of cell receptors that support these processes, as well as membrane penetration. As a result of these extensive studies, adenovirus vectors were among the first to be developed for therapeutic applications. We highlight some of the early (unsuccessful) trials and the lessons learned from them.
(© 2019 Federation of European Biochemical Societies.)

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Keywords: adenovirus; molecular biology; virology

0 (Receptors, Cell Surface)

Date Created: 20191129 Date Completed: 20200618 Latest Revision: 20200618

20231215

10.1002/1873-3468.13700

31777951