The EffectiveNess of LIfestyle with Diet and Physical Activity Education ProGram Among Prehypertensives and Stage 1 HyperTENsives in an Urban Community Setting (ENLIGHTEN) Study.

Publisher: Springer Country of Publication: Netherlands NLM ID: 7600747 Publication Model: Print Cited Medium: Internet ISSN: 1573-3610 (Electronic) Linking ISSN: 00945145 NLM ISO Abbreviation: J Community Health Subsets: MEDLINE

Publication: Amsterdam : Springer
Original Publication: New York, Human Sciences Press.

Diet* ; Exercise* ; Life Style*; Cardiovascular Diseases/*prevention & control ; Health Promotion/*methods; Adult ; Anthropometry ; Blood Pressure ; Female ; Humans ; Hypertension ; Male ; Middle Aged ; Philippines ; Urban Health Services ; Waist Circumference

This study aims to determine the effectiveness of a monthly lifestyle education program, which included advice on nutritional changes and physical activity enhancement in the reduction of blood pressure and selected biochemical and anthropometric parameters among pre-hypertensive and stage 1 hypertensive participants in Manila, Philippines. Participants resided in two barangays (districts), in Manila, Philippines, and each barangay was assigned to either the intervention or attention-control group. The intervention group received monthly lectures on cardiovascular disease and organized classes on diet and exercise, while the attention-control group received monthly lectures on non-cardiovascular topics, with verbal advice that healthy diet and exercise are important. The primary outcome was systolic blood pressure, with secondary outcomes of BMI, waist circumference, and laboratory measures. Linear mixed effects models with an interaction between intervention group and time were used to estimate the 6-month change in each group. At 6 months, systolic blood pressure was lower in the intervention group compared to the attention-control group (- 12.7 mmHg (95% CI [- 14.5, - 10.9]) vs. - 0.24 mmHg (95% CI [- 1.87, 1.43]), p-value < 0.001). Waist circumference (p < 0.001), BMI (p < 0.001), and total cholesterol (p = 0.049) were also lower. However, no statistically significant difference in fasting glucose was observed between the two groups (p = 0.740). This study showed that participants receiving a non-pharmacological intervention, specifically a low-cost diet and active lifestyle education program, experienced a greater decrease in blood pressure, BMI, waist circumference, and total cholesterol than the attention-control group. Educational programs such as in ENLIGHTEN show promise for a developing country with limited resources to improve hypertension levels, and ultimately cardiovascular health. ENLIGHTEN deserves further study in randomized trials.

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K24 HL150476 United States HL NHLBI NIH HHS; UL1 TR001085 United States TR NCATS NIH HHS; P30 DK116074 United States DK NIDDK NIH HHS; R01 MD007012 United States MD NIMHD NIH HHS; UL1 TR003142 United States TR NCATS NIH HHS

Keywords: Hypertension; Lecture; Lifestyle intervention; Non-randomized interventional study; Philippines; Quasi-experimental study

Date Created: 20191103 Date Completed: 20210414 Latest Revision: 20210424

20231215

PMC8061291

10.1007/s10900-019-00764-0

31677046