Role of melatonin in controlling angiogenesis under physiological and pathological conditions.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Ma Q;Ma Q;Ma Q; Reiter RJ; Reiter RJ; Chen Y; Chen Y
  • Source:
    Angiogenesis [Angiogenesis] 2020 May; Vol. 23 (2), pp. 91-104. Date of Electronic Publication: 2019 Oct 24.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer Country of Publication: Germany NLM ID: 9814575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7209 (Electronic) Linking ISSN: 09696970 NLM ISO Abbreviation: Angiogenesis Subsets: MEDLINE
    • Publication Information:
      Publication: Dec. 2004- : Berlin : Springer
      Original Publication: London ; Philadelphia : Rapid Science Publishers,
    • Subject Terms:
      Neovascularization, Pathologic*/genetics ; Neovascularization, Pathologic*/pathology ; Neovascularization, Physiologic*/drug effects ; Neovascularization, Physiologic*/genetics; Melatonin/*physiology; Animals ; Cell Differentiation/drug effects ; Cell Differentiation/genetics ; Cell Movement/drug effects ; Cell Movement/genetics ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Endothelial Cells/drug effects ; Endothelial Cells/physiology ; Humans ; Melatonin/pharmacology ; Neoplasms/blood supply ; Neoplasms/genetics ; Neoplasms/pathology
    • Abstract:
      Angiogenesis depends on proangiogenic and anti-angiogenic molecules that regulate endothelial cell proliferation and migration. Well-regulated angiogenesis plays a pivotal role in many physiological conditions such as reproduction and embryonic development, while abnormal angiogenesis is also the basis of a variety of pathological processes including tumor metastasis and atherosclerotic plaque formation. Melatonin has a variety of biological effects, including inhibition of tumor metastasis, stabilizing atherosclerotic plaques, and the regulation of seasonal reproductive rhythms, etc. During certain pathophysiological processes, melatonin exerts different functions depending on its ability to regulate angiogenesis. This review reveals that melatonin has different effects on neovascularization under different physiological and pathological conditions. In tumors, in age-related ocular diseases, and in a hypoxic environment, melatonin inhibits neovascularization in tissues, while in gastric ulcers, skin lesions, and some physiologic processes, it promotes angiogenesis. We also speculate that melatonin may inhibit the neovascularization in atherosclerotic plaques, thus preventing the initiation and development of atherosclerosis. Most studies suggest that these effects are related to the role of melatonin in regulating of vascular endothelial growth factor and its receptors, but the specific regulatory mechanisms remain disparate, which may lead to the differential effects of melatonin on angiogenesis under different conditions. In this review, we thus summarize some seemingly contradictory mechanisms by which melatonin controls angiogenesis under different pathological and physiological conditions, and urge that the regulatory mechanisms be further studied.
    • Grant Information:
      81827808 International National Natural Science Foundation of China; 81870178 International National Natural Science Foundation of China
    • Contributed Indexing:
      Keywords: Angiogenesis; Atherosclerosis; Hypoxia-inducible factor 1 alpha; Melatonin; Vascular endothelial growth factor
    • Accession Number:
      JL5DK93RCL (Melatonin)
    • Publication Date:
      Date Created: 20191026 Date Completed: 20210113 Latest Revision: 20210113
    • Publication Date:
      20231215
    • Accession Number:
      10.1007/s10456-019-09689-7
    • Accession Number:
      31650428