Vasodilatory effect and structural-activity relationship of a group of iridoid glucosides from Phlomis likiangensis.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE
    • Publication Information:
      Publication: 1999- : [Amsterdam] : Elsevier
      Original Publication: Milano : Inverni & Della Beffa S.p.A.
    • Subject Terms:
      Iridoid Glucosides/*pharmacology ; Phlomis/*chemistry ; Vasodilator Agents/*pharmacology; Animals ; Aorta/drug effects ; Cells, Cultured ; China ; Endothelial Cells/drug effects ; In Vitro Techniques ; Iridoid Glucosides/chemistry ; Male ; Molecular Structure ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Plants, Medicinal/chemistry ; Rats ; Rats, Sprague-Dawley ; Rhizome/chemistry ; Structure-Activity Relationship ; Vasodilation ; Vasodilator Agents/chemistry
    • Abstract:
      As a folk medicine, Phlomis likiangensis is traditionally used in China to activate collaterals and protect cardiovascular system. We hypothesized that the beneficial effects of Phlomis likiangensis may be related to vasodilatation. In the present study, twelve known iridoid glucosides (1-12) were isolated from Phlomis likiangensis. The vasodilatory effects and the underlying mechanisms of the main components (iridoid glucosides) of Phlomis likiangensis on rat aortic rings were investigated. The result showed that iridoid glucosides significantly increased the vasodilatation in rat aortic rings, which was abolished by removing the endothelium of the vessels or by eliminating the generation of nitric oxide. Finally, the structure-activity relationship of compounds 1-12 was also speculated. Our findings provide the first evidence that the iridoid glucosides of Phlomis likiangensis may be the pharmacodynamic basis for its traditional efficacy.
      (Copyright © 2019. Published by Elsevier B.V.)
    • Contributed Indexing:
      Keywords: Iridoid glucosides; Mechanisms; Phlomis likiangensis; Structure-activity relationship; Vasodilatation
    • Accession Number:
      0 (Iridoid Glucosides)
      0 (Vasodilator Agents)
      31C4KY9ESH (Nitric Oxide)
      EC 1.14.13.39 (Nitric Oxide Synthase Type III)
      EC 1.14.13.39 (Nos3 protein, rat)
    • Publication Date:
      Date Created: 20191025 Date Completed: 20191223 Latest Revision: 20191223
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.fitote.2019.104365
    • Accession Number:
      31647954