Multidisciplinary management improves anxiety, depression, medication adherence, and quality of life among patients with epilepsy in eastern China: A prospective study.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: United States NLM ID: 100892858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-5069 (Electronic) Linking ISSN: 15255050 NLM ISO Abbreviation: Epilepsy Behav Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Diego, CA : Academic Press, c2000-
    • Subject Terms:
      Anticonvulsants/*therapeutic use ; Anxiety/*prevention & control ; Depression/*prevention & control ; Epilepsy/*therapy ; Medication Adherence/*psychology ; Quality of Life/*psychology; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anxiety/diagnosis ; Anxiety/epidemiology ; Anxiety/etiology ; China ; Combined Modality Therapy ; Depression/diagnosis ; Depression/epidemiology ; Depression/etiology ; Epilepsy/complications ; Epilepsy/psychology ; Female ; Follow-Up Studies ; Humans ; Interdisciplinary Communication ; Male ; Medication Adherence/statistics & numerical data ; Middle Aged ; Patient Care Team ; Prospective Studies ; Psychiatric Status Rating Scales ; Self Report ; Single-Blind Method ; Treatment Outcome ; Young Adult
    • Abstract:
      Objective: The objective of this study was to investigate the effect of a multidisciplinary program on anxiety, depression, medication adherence, and quality of life in patients with epilepsy in eastern China.
      Methods: A cohort of 184 patients with epilepsy from the epilepsy clinic of a tertiary hospital in eastern China completed this program, out of which 92 were randomized into the intervention group and 92 the control group. Patients in both groups received standard antiepileptic drugs (AEDs), while those of the intervention group received an additional 12-month multidisciplinary program developed by a group of the epileptologist, pharmacist, psychiatrist, and epilepsy specialist nurse. Patients were assessed both before and after the 12-month period. The Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), and the eight-item Morisky Medication Adherence Scale (MMAS-8) were used to assess the severity of depression, anxiety, and medication adherence, respectively, along with Quality of life in Epilepsy-31 (QOLIE-31) and self-reported seizure frequency for life quality and seizure severity.
      Results: The 12-month multidisciplinary program significantly reduced the number of patients with severe depression (p = 0.013) and anxiety (p = 0.002), increased the number of patients with moderate-to-high AED adherence (p = 0.006) and the overall QOLIE-31 score (p < 0.001) in the intervention group. Both groups demonstrated a significant increase in the number of patients with a low seizure frequency after the 12-month period (p < 0.001).
      Conclusion: The 12-month multidisciplinary program offers an effective management strategy in improving psychiatric comorbidities, medication adherence, and quality of life in patients with epilepsy in eastern China.
      (Copyright © 2019 Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Anxiety; Depression; Epilepsy; Medication adherence; Multidisciplinary; Quality of life
    • Accession Number:
      0 (Anticonvulsants)
    • Publication Date:
      Date Created: 20191022 Date Completed: 20200731 Latest Revision: 20200731
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.yebeh.2019.07.001
    • Accession Number:
      31634729