pH-Responsive Nanoprobe for In Vivo Photoacoustic Imaging of Gastric Acid.

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  • Additional Information
    • Source:
      Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, American Chemical Society.
    • Subject Terms:
      Hydrogen-Ion Concentration*; Gastric Acid/*chemistry ; Molecular Probes/*chemistry ; Nanoparticles/*chemistry ; Photoacoustic Techniques/*methods; Animals ; Cell Line ; Humans ; Mice ; Spectrum Analysis/methods
    • Abstract:
      In vivo real-time monitoring gastric acid is of great importance for diagnosis and treatment of gastrointestinal diseases. Herein, we synthesized a pH-responsive photoacoustic (PA) nanoprobe (denoted as LET-4) based on near-infrared (NIR) dye (IR1061) for in vivo photoacoustic imaging (PAI) of gastric acid in living subjects. In the acidic condition, the protonated LET-4 nanoprobe has a strong absorbance peak at 808 nm, followed by a strong PA signal output at 808 nm. The PA808 signal at pH 3 is 3.45-fold higher than the signal at pH 7. More importantly, the LET-4 nanoprobe could monitor in vivo gastric acid secretion assessment in animal model using PAI. This organic small molecule NIR dye-based probe with simple components, facile preparation, good biocompatibility, and rapid excretion has great potential for gastrointestinal disease diagnosis.
    • Accession Number:
      0 (Molecular Probes)
    • Publication Date:
      Date Created: 20191016 Date Completed: 20201014 Latest Revision: 20201014
    • Publication Date:
      20221213
    • Accession Number:
      10.1021/acs.analchem.9b02701
    • Accession Number:
      31610654