Smart textiles in wound care: functionalization of cotton/PET blends with antimicrobial nanocapsules.

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  • Additional Information
    • Source:
      Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101598493 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2050-7518 (Electronic) Linking ISSN: 2050750X NLM ISO Abbreviation: J Mater Chem B Subsets: MEDLINE
    • Publication Information:
      Original Publication: Cambridge : Royal Society of Chemistry
    • Subject Terms:
      Cotton Fiber*/toxicity; Anti-Bacterial Agents/*pharmacology ; Eugenol/*pharmacology ; Nanocapsules/*chemistry ; Polyethylene Terephthalates/*chemistry ; Smart Materials/*pharmacology; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/toxicity ; Bandages ; Carboxylic Ester Hydrolases/chemistry ; Cell Line ; Cellulase/chemistry ; Drug Delivery Systems ; Drug Liberation ; Escherichia coli/drug effects ; Eugenol/chemistry ; Eugenol/toxicity ; Fibroins/chemistry ; Fibroins/toxicity ; Humans ; Nanocapsules/toxicity ; Polyethylene Terephthalates/toxicity ; Serum Albumin, Human/chemistry ; Serum Albumin, Human/toxicity ; Smart Materials/chemistry ; Smart Materials/toxicity ; Staphylococcus aureus/drug effects
    • Abstract:
      Management of infected wounds is one of the most costly procedures in the health care sector. Burn wounds are of significant importance due to the high infection risk that can possibly lead to severe consequences such as sepsis. Because antibiotic wound treatments have caused increasing antibiotic resistance in bacteria, there is currently a strong need for alternative strategies. Therefore, we developed new antimicrobial wound dressings consisting of pH-responsive human serum albumin/silk fibroin nanocapsules immobilized onto cotton/polyethylene terephthalate (PET) blends loaded with eugenol, which is an antimicrobial phenylpropanoid. Ultrasound-assisted production of eugenol-loaded nanocapsules resulted in particle sizes (hydrodynamic radii) between 319.73 ± 17.50 and 574.00 ± 92.76 nm and zeta potentials ranging from -10.39 ± 1.99 mV to -12.11 ± 0.59 mV. Because recent discoveries have indicated that the sweat glands contribute to wound reepithelialisation, release studies of eugenol were conducted in different artificial sweat formulas that varied in pH. Formulations containing 10% silk fibroin with lower degradation degree exhibited the highest release of 41% at pH 6.0. After immobilization, the functionalized cotton/PET blends were able to inhibit 81% of Staphylococcus aureus and 33% of Escherichia coli growth. Particle uniformity, silk fibroin concentration, and high surface-area-to-volume ratio of the produced nanocapsules were identified as the contributing factors leading to high antimicrobial activities against both strains. Therefore, the production of antimicrobial textiles using nanocapsules loaded with an active natural compound that will not contribute to antibiotic resistance is seen as a potential future alternative to commercially available antiseptic wound dressings.
    • Accession Number:
      0 (Anti-Bacterial Agents)
      0 (Nanocapsules)
      0 (Polyethylene Terephthalates)
      0 (Smart Materials)
      3T8H1794QW (Eugenol)
      9007-76-5 (Fibroins)
      EC 3.1.1.- (Carboxylic Ester Hydrolases)
      EC 3.1.1.- (cutinase)
      EC 3.2.1.4 (Cellulase)
      ZIF514RVZR (Serum Albumin, Human)
    • Publication Date:
      Date Created: 20191008 Date Completed: 20200922 Latest Revision: 20200922
    • Publication Date:
      20240829
    • Accession Number:
      10.1039/c9tb01474h
    • Accession Number:
      31589221