Effects of a toothpaste containing 0.3% triclosan on periodontal parameters of subjects enrolled in a regular maintenance program: A secondary analysis of a 2-year randomized clinical trial.

Publisher: American Academy of Periodontology Country of Publication: United States NLM ID: 8000345 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1943-3670 (Electronic) Linking ISSN: 00223492 NLM ISO Abbreviation: J Periodontol Subsets: MEDLINE

Original Publication: [Chicago] American Academy of Periodontology.

Anti-Infective Agents, Local* ; Dental Plaque* ; Dentifrices* ; Peri-Implantitis* ; Triclosan*; Double-Blind Method ; Fluorides ; Humans ; Sodium Fluoride ; Toothpastes

Background: The triclosan-containing dentifrices are effective in controlling biofilm formation and maintaining gingival health; however, there is limited information on their effects during the periodontal maintenance phase. Therefore, the aim of this study was to evaluate the clinical effects of a toothpaste containing 0.3% triclosan on the periodontal parameters of subjects that have been treated for peri-implantitis and were enrolled in a regular maintenance program.
Methods: Subjects presenting at least one implant with peri-implantitis and received surgical anti-infective therapy were selected. Sixty days post-surgery (baseline), subjects were randomized into two groups: (1) toothpaste containing 0.3% triclosan + 2.0% PVM/MA copolymer + 1450 ppm fluoride (test) or (2) toothpaste containing 1450 ppm fluoride (control), and were instructed to brush with the assigned toothpaste twice/day for 2 years. They received clinical monitoring at baseline, 3, 6, 12, 18, and 24 months, and professional maintenance every 3 months.
Results: Eighty-eight subjects with natural teeth were enrolled in the study (Test, n = 39; Control, n = 49). The test group showed a greater reduction in the percentage of sites exhibiting bleeding on probing (primary outcome) and lower levels of plaque in comparison with the control group after 24 months (P < 0.05). The mean percentage of sites with probing depth ≥5 mm was reduced over the course of the study only in the test group (P < 0.05).
Conclusion: A toothpaste containing 0.3% triclosan was more effective than a regular fluoride toothpaste in improving the periodontal clinical condition around natural teeth of periodontally healthy subjects enrolled in a regular maintenance program for 2 years.
(© 2019 American Academy of Periodontology.)

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Keywords: periodontal disease; periodontitis; toothpaste; triclosan

0 (Anti-Infective Agents, Local)
0 (Dentifrices)
0 (Toothpastes)
4NM5039Y5X (Triclosan)
8ZYQ1474W7 (Sodium Fluoride)
Q80VPU408O (Fluorides)

Date Created: 20190928 Date Completed: 20200914 Latest Revision: 20200914

20240829

10.1002/JPER.18-0501

31560794