Distribution analysis of single nucleotide polymorphisms related to feet and legs and their association with lameness in Vrindavani cattle.

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  • Additional Information
    • Source:
      Publisher: Springer Country of Publication: United States NLM ID: 1277355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7438 (Electronic) Linking ISSN: 00494747 NLM ISO Abbreviation: Trop Anim Health Prod Subsets: MEDLINE
    • Publication Information:
      Publication: 2005- : Heidelberg : Springer
      Original Publication: Edinburgh, Livingstone.
    • Subject Terms:
      Polymorphism, Restriction Fragment Length* ; Polymorphism, Single Nucleotide*; Cattle Diseases/*genetics ; Lameness, Animal/*genetics; Animals ; Cattle ; Cattle Diseases/epidemiology ; Dairying ; Female ; Foot/physiopathology ; Forelimb/physiopathology ; Hindlimb/physiopathology ; India/epidemiology ; Lameness, Animal/epidemiology ; Prevalence
    • Abstract:
      Lameness is one of the most serious economic problems in dairy animals. The present study was undertaken to identify the SNPs associated with lameness in Vrindavani, a synthetic crossbred cattle developed in India. A total of 187 cows were screened for lameness at Cattle and Buffalo Farm, Indian Veterinary Research Institute, Izatnagar, India and 16.04% prevalence was noticed. The effect of age, body weight, parity, and peak yield was not significant on lameness score. Heritability estimate of lameness score was low (0.07 ± 0.01). A total of 90 Vrindavani cows were genotyped by PCR-RFLP for 10 SNPs that were reported to have association with feet and legs in cattle. Five SNPs displayed significant departure from Hardy Weinberg equilibrium. Varying levels of heterozygosity, polymorphic information content, and allelic diversity were noticed at different SNPs. Odds ratio and least squares analysis revealed a significant association (P < 0.05) of three SNPs with lameness in the herd. Cows with AG, TT, and GG genotypes respectively at rs41632254, rs41603160, and rs41636945 loci were less prone to lameness. These genetic markers would certainly aid in development of an early detection system for lameness.
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    • Contributed Indexing:
      Keywords: Lameness score; PCR-RFLP; SNP markers; Vrindavani
    • Publication Date:
      Date Created: 20190915 Date Completed: 20200731 Latest Revision: 20200731
    • Publication Date:
      20240829
    • Accession Number:
      10.1007/s11250-019-02076-w
    • Accession Number:
      31520341