Decreased glomerular filtration rate in patients with at least 5 years of type 2 diabetes in Ho Chi Minh City, Vietnam: Prevalence and associated factors.

Publisher: Elsevier Country of Publication: England NLM ID: 101463825 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0210 (Electronic) Linking ISSN: 18780210 NLM ISO Abbreviation: Prim Care Diabetes Subsets: MEDLINE

Original Publication: Kidlington, Oxford : Elsevier

Glomerular Filtration Rate*; Albuminuria/*epidemiology ; Diabetes Mellitus, Type 2/*epidemiology ; Diabetic Nephropathies/*epidemiology ; Kidney/*physiopathology ; Renal Insufficiency, Chronic/*epidemiology; Aged ; Albuminuria/diagnosis ; Albuminuria/physiopathology ; Diabetes Mellitus, Type 2/diagnosis ; Diabetic Nephropathies/diagnosis ; Diabetic Nephropathies/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Prognosis ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/physiopathology ; Risk Assessment ; Risk Factors ; Time Factors ; Vietnam/epidemiology

Aims: This study determined the prevalence and associated factors of decreased estimated glomerular filtration rate (eGFR) in patients who had type 2 diabetes for at least 5 years.
Methods: A cohort study was conducted in 467 outpatients in a community-based hospital in Ho Chi Minh City, Vietnam. Serum creatinine were tested twice, at two occasions at least 3 months apart. The confirmatory eGFR was the average of the two eGFR of which the difference was ≤20%. The mean urine albumin-to-creatinine ratio was calculated from two consecutive early morning specimens.
Results: Most patients were female with a mean age of 61.7 (8.0) years. Albuminuria was found in 40% of participants, and the prevalence of decreased eGFR was 7.5% (n=35). Individuals with declined eGFR were older (p<0.001), had duration of diabetes longer (p=0.025), higher systolic blood pressure (p=0.010) and higher acid uric level (p<0.001), increased albumin excretion (p=0.009), and more proliferative retinopathy (p=0.011) than those with non-declined eGFR.
Conclusions: Although decreased eGFR in type 2 diabetes patients was not prevalent, the strategies to prevent the progressive decline of GFR should be done to prevent patients from progressing to advanced renal disease.
(Copyright © 2019 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.)

Keywords: Decline in eGFR; Decreased estimated glomerular filtration rate; Type 2 diabetes

Date Created: 20190909 Date Completed: 20210408 Latest Revision: 20210408

20231215

10.1016/j.pcd.2019.08.003

31494076