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Improved home BP profile with dapagliflozin is associated with amelioration of albuminuria in Japanese patients with diabetic nephropathy: the Yokohama add-on inhibitory efficacy of dapagliflozin on albuminuria in Japanese patients with type 2 diabetes study (Y-AIDA study).
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- Author(s): Kinguchi S;Kinguchi S; Wakui H; Wakui H; Ito Y; Ito Y; Kondo Y; Kondo Y; Azushima K; Azushima K; Osada U; Osada U; Yamakawa T; Yamakawa T; Iwamoto T; Iwamoto T; Yutoh J; Yutoh J; Misumi T; Misumi T; Aoki K; Aoki K; Yasuda G; Yasuda G; Yoshii T; Yoshii T; Yamada T; Yamada T; Ono S; Ono S; Shibasaki-Kurita T; Shibasaki-Kurita T; Hosokawa S; Hosokawa S; Orime K; Orime K; Hanaoka M; Hanaoka M; Sasaki H; Sasaki H; Inazumi K; Inazumi K; Yamada T; Yamada T; Kobayashi R; Kobayashi R; Ohki K; Ohki K; Haruhara K; Haruhara K; Kobayashi Y; Kobayashi Y; Kobayashi Y; Yamanaka T; Yamanaka T; Terauchi Y; Terauchi Y; Tamura K; Tamura K
- Source:
Cardiovascular diabetology [Cardiovasc Diabetol] 2019 Aug 27; Vol. 18 (1), pp. 110. Date of Electronic Publication: 2019 Aug 27.- Publication Type:
Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: BioMed Central Country of Publication: England NLM ID: 101147637 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2840 (Electronic) Linking ISSN: 14752840 NLM ISO Abbreviation: Cardiovasc Diabetol Subsets: MEDLINE
- Publication Information: Original Publication: London : BioMed Central, [2002-
- Subject Terms: Albuminuria/*drug therapy ; Benzhydryl Compounds/*therapeutic use ; Blood Pressure/*drug effects ; Diabetes Mellitus, Type 2/*drug therapy ; Diabetic Nephropathies/*drug therapy ; Glucosides/*therapeutic use ; Kidney/*drug effects ; Sodium-Glucose Transporter 2 Inhibitors/*therapeutic use; Adult ; Aged ; Albuminuria/diagnosis ; Albuminuria/epidemiology ; Albuminuria/physiopathology ; Benzhydryl Compounds/adverse effects ; Biomarkers/blood ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Blood Pressure Monitoring, Ambulatory ; Circadian Rhythm ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/physiopathology ; Diabetic Nephropathies/diagnosis ; Diabetic Nephropathies/epidemiology ; Diabetic Nephropathies/physiopathology ; Female ; Glomerular Filtration Rate/drug effects ; Glucosides/adverse effects ; Glycated Hemoglobin/metabolism ; Humans ; Japan/epidemiology ; Kidney/physiopathology ; Male ; Middle Aged ; Prospective Studies ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Time Factors ; Treatment Outcome ; Young Adult
- Abstract: Background: The Y-AIDA study was designed to investigate the renal- and home blood pressure (BP)-modulating effects of add-on dapagliflozin treatment in Japanese individuals with type 2 diabetes mellitus (T2DM) and albuminuria.
Methods: We conducted a prospective, multicenter, single-arm study. Eighty-six patients with T2DM, HbA1c 7.0-10.0%, estimated glomerular filtration rate (eGFR) ≥ 45 mL/min/1.73 m 2 , and urine albumin-to-creatinine ratio (UACR) ≥ 30 mg/g creatinine (gCr) were enrolled, and 85 of these patients were administered add-on dapagliflozin for 24 weeks. The primary and key secondary endpoints were change from baseline in the natural logarithm of UACR over 24 weeks and change in home BP profile at week 24.
Results: Baseline median UACR was 181.5 mg/gCr (interquartile range 47.85, 638.0). Baseline morning, evening, and nocturnal home systolic/diastolic BP was 137.6/82.7 mmHg, 136.1/79.3 mmHg, and 125.4/74.1 mmHg, respectively. After 24 weeks, the logarithm of UACR decreased by 0.37 ± 0.73 (P < 0.001). In addition, changes in morning, evening, and nocturnal home BP from baseline were as follows: morning systolic/diastolic BP - 8.32 ± 11.42/- 4.18 ± 5.91 mmHg (both P < 0.001), evening systolic/diastolic BP - 9.57 ± 12.08/- 4.48 ± 6.45 mmHg (both P < 0.001), and nocturnal systolic/diastolic BP - 2.38 ± 7.82/- 1.17 ± 5.39 mmHg (P = 0.0079 for systolic BP, P = 0.0415 for diastolic BP). Furthermore, the reduction in UACR after 24 weeks significantly correlated with an improvement in home BP profile, but not with changes in other variables, including office BP. Multivariate linear regression analysis also revealed that the change in morning home systolic BP was a significant contributor to the change in log-UACR.
Conclusions: In Japanese patients with T2DM and diabetic nephropathy, dapagliflozin significantly improved albuminuria levels and the home BP profile. Improved morning home systolic BP was associated with albuminuria reduction. Trial registration The study is registered at the UMIN Clinical Trials Registry (UMIN000018930; http://www.umin.ac.jp/ctr/index-j.htm ). The study was conducted from July 1, 2015 to August 1, 2018. - References: Diabetes Obes Metab. 2015 Dec;17(12):1180-93. (PMID: 26343814)
Cardiovasc Diabetol. 2017 Jul 6;16(1):84. (PMID: 28683796)
Horm Res Paediatr. 2012;78(3):158-64. (PMID: 23052543)
BMJ Open. 2013 Dec 23;3(12):e003733. (PMID: 24366578)
J Am Soc Nephrol. 2017 Jan;28(1):368-375. (PMID: 27539604)
BMC Pharmacol Toxicol. 2017 Apr 10;18(1):23. (PMID: 28391776)
Diabetes Obes Metab. 2016 Jun;18(6):590-7. (PMID: 26936519)
Circulation. 1999 Oct 12;100(15):1635-8. (PMID: 10517735)
Int J Mol Sci. 2013 Aug 16;14(8):16866-81. (PMID: 23959116)
N Engl J Med. 2019 Jan 24;380(4):347-357. (PMID: 30415602)
N Engl J Med. 2016 Jul 28;375(4):323-34. (PMID: 27299675)
Diabetes Care. 2015 Mar;38(3):420-8. (PMID: 25271206)
Lancet Diabetes Endocrinol. 2014 May;2(5):369-84. (PMID: 24795251)
Hypertension. 2018 Jan;71(1):177-184. (PMID: 29133364)
Ann Intern Med. 2012 Mar 20;156(6):405-15. (PMID: 22431673)
Diabetes Obes Metab. 2015 Mar;17(3):294-303. (PMID: 25495720)
Diabetes. 2007 Jun;56(6):1727-30. (PMID: 17360976)
Am J Cardiol. 2014 Mar 15;113(6):1058-65. (PMID: 24462067)
Hypertens Res. 2018 Mar;41(3):198-208. (PMID: 29382900)
Kidney Int. 2018 Nov;94(5):912-925. (PMID: 30021702)
Acta Physiol (Oxf). 2019 Apr;225(4):e13249. (PMID: 30597733)
Lancet Diabetes Endocrinol. 2016 Mar;4(3):211-220. (PMID: 26620248)
Diabetes Obes Metab. 2013 May;15(5):463-73. (PMID: 23464594)
Hypertension. 2008 Dec;52(6):1045-50. (PMID: 18981332)
N Engl J Med. 2017 Aug 17;377(7):644-657. (PMID: 28605608)
J Clin Med Res. 2016 Feb;8(2):116-25. (PMID: 26767080)
J Diabetes. 2017 Aug;9(8):787-799. (PMID: 27625142)
Curr Cardiol Rep. 2013 Nov;15(11):413. (PMID: 24057836)
Lancet Diabetes Endocrinol. 2017 Aug;5(8):610-621. (PMID: 28666775)
Cardiovasc Diabetol. 2019 Apr 5;18(1):46. (PMID: 30953516)
Cardiovasc Diabetol. 2018 Jan 4;17(1):5. (PMID: 29301520)
N Engl J Med. 2019 Jun 13;380(24):2295-2306. (PMID: 30990260)
J Clin Hypertens (Greenwich). 2016 Jan;18(1):43-52. (PMID: 26663712)
N Engl J Med. 2015 Nov 26;373(22):2117-28. (PMID: 26378978)
Am J Physiol Endocrinol Metab. 2017 Nov 1;313(5):E563-E576. (PMID: 28811292)
Clin Exp Hypertens. 2012;34(4):264-9. (PMID: 22578052)
Kidney Int. 2006 Apr;69(7):1175-80. (PMID: 16467785)
Clin J Am Soc Nephrol. 2017 May 8;12(5):751-759. (PMID: 28302903)
Kidney Int. 2006 Jan;69(2):406-11. (PMID: 16408134)
Diabetes Care. 2017 Oct;40(10):1364-1372. (PMID: 28751548)
Diabetes Care. 2017 Sep;40(9):1273-1284. (PMID: 28830958)
Curr Ther Res Clin Exp. 2017 Jul 08;87:13-19. (PMID: 28912902)
Diabetologia. 2011 May;54(5):1025-31. (PMID: 21286682)
Cardiovasc Diabetol. 2017 Feb 27;16(1):29. (PMID: 28241822)
Lancet. 2016 Apr 9;387(10027):1513-1530. (PMID: 27061677)
J Am Soc Nephrol. 2009 Feb;20(2):299-310. (PMID: 19073825)
Blood Press. 2016;25(2):93-103. (PMID: 26623980)
Diabetes Obes Metab. 2015 Aug;17(8):805-8. (PMID: 25951755)
Cardiovasc Diabetol. 2017 May 16;16(1):65. (PMID: 28511711)
Hypertens Res. 2013 Mar;36(3):262-9. (PMID: 23154587)
Hypertension. 2005 Jul;46(1):156-61. (PMID: 15939805)
Cardiovasc Diabetol. 2017 Feb 23;16(1):26. (PMID: 28231831)
Circ J. 2017 Jun 23;81(7):948-957. (PMID: 28321001)
Hypertens Res. 2011 Dec;34(12):1271-5. (PMID: 21814212)
Eur Heart J. 2011 Jun;32(12):1493-9. (PMID: 21421598)
Hypertens Res. 2003 Jul;26(7):521-5. (PMID: 12924618)
Kidney Dis (Basel). 2015 May;1(1):52-60. (PMID: 27536665)
Clin Exp Hypertens. 2016;38(8):744-750. (PMID: 27936999)
J Hypertens. 2018 May;36(5):1068-1075. (PMID: 29283972)
Am J Hypertens. 2013 May;26(5):665-72. (PMID: 23391621)
Diabetes Obes Metab. 2013 Sep;15(9):853-62. (PMID: 23668478)
Lancet. 2010 Jun 26;375(9733):2215-22. (PMID: 20609967)
Blood Press Monit. 2015 Oct;20(5):286-90. (PMID: 25932887)
J Diabetes Complications. 2016 May-Jun;30(4):738-45. (PMID: 26781070)
Am J Kidney Dis. 2009 Jun;53(6):982-92. (PMID: 19339088)
Diabetes Obes Metab. 2019 May;21(5):1237-1250. (PMID: 30697905)
Diabetes Metab Syndr. 2018 Nov;12(6):1117-1123. (PMID: 29909004)
Nephrol Dial Transplant. 2019 Apr 21;:. (PMID: 31005993)
Diabetes Obes Metab. 2017 Oct;19(10):1363-1370. (PMID: 28295959)
Cardiovasc Diabetol. 2017 Oct 23;16(1):138. (PMID: 29061124)
Circulation. 2018 Nov 29;:. (PMID: 30586745)
J Am Heart Assoc. 2017 May 18;6(5):. (PMID: 28522675)
Lancet. 2016 Jan 30;387(10017):435-43. (PMID: 26559744) - Contributed Indexing: Keywords: Albuminuria; Blood pressure; Diabetic nephropathy; SGLT2 inhibitor; Type 2 diabetes mellitus
- Molecular Sequence: JPRN UMIN000018930
- Accession Number: 0 (Benzhydryl Compounds)
0 (Biomarkers)
0 (Blood Glucose)
0 (Glucosides)
0 (Glycated Hemoglobin A)
0 (Sodium-Glucose Transporter 2 Inhibitors)
0 (hemoglobin A1c protein, human)
1ULL0QJ8UC (dapagliflozin) - Publication Date: Date Created: 20190829 Date Completed: 20200511 Latest Revision: 20221207
- Publication Date: 20240628
- Accession Number: PMC6710883
- Accession Number: 10.1186/s12933-019-0912-3
- Accession Number: 31455298
- Source:
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