Cellular senescence: at the nexus between ageing and diabetes.

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  • Additional Information
    • Source:
      Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin Springer Verlag
    • Subject Terms:
      Aging/*metabolism ; Cellular Senescence/*physiology ; Diabetes Mellitus, Type 2/*metabolism; Aging/genetics ; Animals ; Cellular Senescence/genetics ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/pathology ; Humans
    • Abstract:
      Ageing and diabetes lead to similar organ dysfunction that is driven by parallel molecular mechanisms, one of which is cellular senescence. The abundance of senescent cells in various tissues increases with age, obesity and diabetes. Senescent cells have been directly implicated in the generation of insulin resistance. Recently, drugs that preferentially target senescent cells, known as senolytics, have been described and recently entered clinical trials. In this review, we explore the biological links between ageing and diabetes, specifically focusing on cellular senescence. We summarise the current data on cellular senescence in key target tissues associated with the development and clinical phenotypes of type 2 diabetes and discuss the therapeutic potential of targeting cellular senescence in diabetes.
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    • Grant Information:
      R33 AG061456 United States AG NIA NIH HHS; R37 AG013925 United States AG NIA NIH HHS; T32 GM065841 United States GM NIGMS NIH HHS
    • Contributed Indexing:
      Keywords: Ageing; Cellular senescence; Dasatinib; Diabetes; Geroscience; Life course development; Quercetin; Review; Senolytics; Type 2 diabetes
    • Publication Date:
      Date Created: 20190828 Date Completed: 20200601 Latest Revision: 20201106
    • Publication Date:
      20221213
    • Accession Number:
      PMC6731336
    • Accession Number:
      10.1007/s00125-019-4934-x
    • Accession Number:
      31451866