The association of the common fat mass and obesity associated gene polymorphisms with type 2 diabetes in obese Iraqi population.

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  • Additional Information
    • Source:
      Publisher: Elsevier Ltd Country of Publication: Netherlands NLM ID: 101462250 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0334 (Electronic) Linking ISSN: 18714021 NLM ISO Abbreviation: Diabetes Metab Syndr Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam : Elsevier Ltd.
    • Subject Terms:
      Genetic Predisposition to Disease* ; Polymorphism, Single Nucleotide*; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/*genetics ; Biomarkers/*analysis ; Diabetes Mellitus, Type 2/*epidemiology ; Diabetes Mellitus, Type 2/*genetics ; Obesity/*complications; Adult ; Aged ; Body Mass Index ; Case-Control Studies ; Female ; Follow-Up Studies ; Gene Frequency ; Genotype ; Humans ; Insulin Resistance ; Iraq ; Male ; Middle Aged ; Prognosis
    • Abstract:
      Background & Objectives: This study investigates the association of two potential Fat mass and obesity associated gene (FTO) gene polymorphisms (rs9939609 and rs918031) as potential predictors of type 2 diabetes (T2D) in obese Iraqi population and their metabolic effects on hyperglycemia and insulin sensitivity.
      Materials & Methods: The study included 400 participants with obesity & T2D, with a matching 400 obese non-diabetic cohort. Venous blood samples were collected for DNA extraction. Using specific primers and restriction enzymes, genotyping was performed to identify the various alleles for each gene. The genotype and allele frequencies determined by multinomial logistic regression analysis for FTO single nucleotide polymorphisms (rs9939609) among all the study groups.
      Results: There is a two-fold increase in the risk of T2D within the homozygous genotype (TT) group (OR = 2.43, CI 95% 3.57-11.2, P ≤ 0.001) as compared to the wild type (TA). In addition, there was a significantly higher level of the minor allele genotype (T) in T2D patients when compared to the control group, (P ≤ 0.001).
      Conclusion: We conclude that the FTO rs9939609 genotype significantly affect the development of insulin resistance, therefore the future occurrence of T2D, in obese individuals.
      (Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Body mass index; Fat mass and obesity associated gene; Type 2 diabetes mellitus
    • Accession Number:
      0 (Biomarkers)
      EC 1.14.11.33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO)
      EC 1.14.11.33 (FTO protein, human)
    • Publication Date:
      Date Created: 20190814 Date Completed: 20200106 Latest Revision: 20200106
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.dsx.2019.06.024
    • Accession Number:
      31405659