Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability.

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  • Additional Information
    • Source:
      Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI Publishing
    • Subject Terms:
      Biological Variation, Individual* ; Diet*/adverse effects ; Dietary Supplements*/adverse effects; Cardiovascular Diseases/*prevention & control ; Coumaric Acids/*administration & dosage ; Metabolic Diseases/*prevention & control; Adult ; Aged ; Biomarkers/blood ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/physiopathology ; Coumaric Acids/adverse effects ; Female ; Humans ; Male ; Metabolic Diseases/blood ; Metabolic Diseases/epidemiology ; Metabolic Diseases/physiopathology ; Middle Aged ; Nutritional Status ; Nutritive Value ; Protective Factors ; Randomized Controlled Trials as Topic ; Risk Factors ; Risk Reduction Behavior ; Young Adult
    • Abstract:
      Plant-based diets rich in bioactive compounds such as polyphenols have been shown to positively modulate the risk of cardiometabolic (CM) diseases. The inter-individual variability in the response to these bioactives may affect the findings. This systematic review aimed to summarize findings from existing randomized clinical trials (RCTs) evaluating the effect of hydroxycinnamic acids (HCAs) on markers of CM health in humans. Literature searches were performed in PubMed and the Web of Science. RCTs on acute and chronic supplementation of HCA-rich foods/extracts on CM biomarkers were included. Forty-four RCTs (21 acute and 23 chronic) met inclusion criteria. Comparisons were made between RCTs, including assessments based on population health status. Of the 44 RCTs, only seven performed analyses on a factor exploring inter-individual response to HCA consumption. Results demonstrated that health status is a potentially important effect modifier as RCTs with higher baseline cholesterol, blood pressure and glycaemia demonstrated greater overall effectiveness, which was also found in studies where specific subgroup analyses were performed. Thus, the effect of HCAs on CM risk factors may be greater in individuals at higher CM risk, although future studies in these populations are needed, including those on other potential determinants of inter-individual variability. PROSPERO, registration number CRD42016050790.
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    • Contributed Indexing:
      Keywords: artichoke; caffeoylquinic acids; cardiometabolic health; cereals; coffee; dietary supplements; hydroxycinnamic acids; interindividual variability; polyphenols; potato
    • Accession Number:
      0 (Biomarkers)
      0 (Coumaric Acids)
    • Publication Date:
      Date Created: 20190808 Date Completed: 20200128 Latest Revision: 20200225
    • Publication Date:
      20240829
    • Accession Number:
      PMC6723370
    • Accession Number:
      10.3390/nu11081805
    • Accession Number:
      31387247