Expression of Matrix Metalloproteinases in Intraductal Papillary Mucinous Neoplasm of the Pancreas.

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  • Additional Information
    • Source:
      Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE
    • Publication Information:
      Publication: Attiki, Greece : International Institute of Anticancer Research
      Original Publication: Athens, Greece : Potamitis Press
    • Subject Terms:
      Matrix Metalloproteinase 1/*genetics ; Matrix Metalloproteinase 2/*genetics ; Matrix Metalloproteinase 7/*genetics ; Matrix Metalloproteinase 9/*genetics ; Pancreatic Intraductal Neoplasms/*genetics; Aged ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Male ; Middle Aged ; Pancreas/metabolism ; Pancreas/pathology ; Pancreatic Intraductal Neoplasms/epidemiology ; Pancreatic Intraductal Neoplasms/pathology
    • Abstract:
      Background/aim: Intraductal papillary mucinous neoplasm (IPMN) has a variety of histological and morphological appearances. Matrix metalloproteinases (MMPs) have been considered to be associated with tumor progression or poor prognosis. The aim of this study was to elucidate the molecular basis of IPMN variation in different types of lesions.
      Materials and Methods: The expression of MMP-1,2,7,9 in 51 cases of IPMN were investigated. The MMP score was calculated as the sum of the score of staining distribution and the score of the intensity staining.
      Results: MMP scores were correlated with histological grade, histological subtype, and type of invasion. MMP high expression groups (MMP score ≥5) had worse prognosis than low-expression groups.
      Conclusion: MMP expression varied between different types of IPMN, a result supporting differences in molecular basis of malignancies. These considerations may be helpful for optimal management or treatment according to various types of IPMN.
      (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
    • Contributed Indexing:
      Keywords: Intraductal papillary mucinous neoplasm; histological grade; histological subtype; immunohistochemistry; matrix metalloproteinases; type of invasion
    • Accession Number:
      EC 3.4.24.23 (MMP7 protein, human)
      EC 3.4.24.23 (Matrix Metalloproteinase 7)
      EC 3.4.24.24 (Matrix Metalloproteinase 2)
      EC 3.4.24.35 (Matrix Metalloproteinase 9)
      EC 3.4.24.7 (Matrix Metalloproteinase 1)
    • Publication Date:
      Date Created: 20190802 Date Completed: 20190806 Latest Revision: 20190806
    • Publication Date:
      20221213
    • Accession Number:
      10.21873/anticanres.13623
    • Accession Number:
      31366549