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CSF parameters associated with early MRI activity in patients with MS.
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- Author(s): Klein A;Klein A;Klein A;Klein A;Klein A;Klein A;Klein A; Selter RC; Selter RC; Selter RC; Selter RC; Selter RC; Selter RC; Selter RC; Hapfelmeier A; Hapfelmeier A; Hapfelmeier A; Hapfelmeier A; Hapfelmeier A; Hapfelmeier A; Hapfelmeier A; Berthele A; Berthele A; Berthele A; Berthele A; Berthele A; Berthele A; Berthele A; Müller-Myhsok B; Müller-Myhsok B; Müller-Myhsok B; Müller-Myhsok B; Müller-Myhsok B; Müller-Myhsok B; Müller-Myhsok B; Pongratz V; Pongratz V; Pongratz V; Pongratz V; Pongratz V; Pongratz V; Pongratz V; Gasperi C; Gasperi C; Gasperi C; Gasperi C; Gasperi C; Gasperi C; Gasperi C; Zimmer C; Zimmer C; Zimmer C; Zimmer C; Zimmer C; Zimmer C; Zimmer C; Mühlau M; Mühlau M; Mühlau M; Mühlau M; Mühlau M; Mühlau M; Mühlau M; Hemmer B; Hemmer B; Hemmer B; Hemmer B; Hemmer B; Hemmer B; Hemmer B
- Source:
Neurology(R) neuroimmunology & neuroinflammation [Neurol Neuroimmunol Neuroinflamm] 2019 May 30; Vol. 6 (4), pp. e573. Date of Electronic Publication: 2019 May 30 (Print Publication: 2019).- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Wolters Kluwer Health/Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101636388 Publication Model: eCollection Cited Medium: Internet ISSN: 2332-7812 (Electronic) Linking ISSN: 23327812 NLM ISO Abbreviation: Neurol Neuroimmunol Neuroinflamm Subsets: MEDLINE
- Publication Information: Original Publication: Baltimore, MD : Wolters Kluwer Health/Lippincott Williams & Wilkins, [2014]-
- Subject Terms: Disease Progression*; Biomarkers/*cerebrospinal fluid ; Demyelinating Diseases/*cerebrospinal fluid ; Demyelinating Diseases/*pathology ; Multiple Sclerosis/*cerebrospinal fluid ; Multiple Sclerosis/*pathology; Adult ; Cohort Studies ; Female ; Humans ; Immunoglobulin A/blood ; Immunoglobulin A/cerebrospinal fluid ; Immunoglobulin A/metabolism ; Immunoglobulin G/blood ; Immunoglobulin G/cerebrospinal fluid ; Immunoglobulin G/metabolism ; Immunoglobulin M/blood ; Immunoglobulin M/cerebrospinal fluid ; Immunoglobulin M/metabolism ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Tumor Necrosis Factor Receptor Superfamily, Member 7/blood ; Tumor Necrosis Factor Receptor Superfamily, Member 7/metabolism
- Abstract: Objective: To identify CSF parameters at diagnosis of clinically isolated syndrome (CIS) and MS that are associated with early inflammatory disease activity as measured by standardized cerebral MRI (cMRI).
Methods: One hundred forty-nine patients with newly diagnosed CIS and MS were included in the retrospective study. cMRI at onset and after 12 months was analyzed for T2 and gadolinium-enhancing lesions. CSF was tested for oligoclonal bands and intrathecal synthesis of immunoglobulin G (IgG), A (IgA), and M (IgM) before initiation of disease-modifying therapy (DMT). In a subgroup of patients, CSF and serum samples were analyzed for sCD27, neurofilament light chain, and IgG subclasses 1 and 3. Association between CSF parameters and cMRI activity was investigated by univariable and multivariable regression analysis in all patients, DMT-treated patients, and untreated patients.
Results: IgG index, sCD27 levels in CSF, and to a lesser extent IgM index were associated with the occurrence of new cMRI lesions. IgG index and sCD27 levels in CSF were highly correlated. In a multivariable analysis, IgG index and to a lesser extent IgM index together with DMT treatment status and gender were strongest predictors of future cMRI activity.
Conclusions: CSF parameters such as IgG and IgM index are independently associated with future MRI activity and thus might be helpful to support early treatment decisions in patients newly diagnosed with CIS and MS. - References: Lancet. 2001 May 19;357(9268):1576-82. (PMID: 11377645)
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Clin Chim Acta. 1987 Mar 30;163(3):319-28. (PMID: 3581475) - Accession Number: 0 (Biomarkers)
0 (Immunoglobulin A)
0 (Immunoglobulin G)
0 (Immunoglobulin M)
0 (Tumor Necrosis Factor Receptor Superfamily, Member 7) - Publication Date: Date Created: 20190730 Date Completed: 20200930 Latest Revision: 20200930
- Publication Date: 20240628
- Accession Number: PMC6624100
- Accession Number: 10.1212/NXI.0000000000000573
- Accession Number: 31355309
- Source:
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