Mycobacterium avium subspecies paratuberculosis seroconversion in dairy cattle and its association with raised somatic cell count.

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  • Additional Information
    • Source:
      Publisher: Wiley Country of Publication: England NLM ID: 0031164 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2042-7670 (Electronic) Linking ISSN: 00424900 NLM ISO Abbreviation: Vet Rec Subsets: MEDLINE
    • Publication Information:
      Publication: 2021- : [Oxford] : Wiley
      Original Publication: -June 2009 : London : British Veterinary Medicine
    • Subject Terms:
      Seroconversion*; Cattle Diseases/*diagnosis ; Mycobacterium avium subsp. paratuberculosis/*immunology ; Paratuberculosis/*diagnosis; Animals ; Case-Control Studies ; Cattle ; Cell Count/veterinary ; Dairying ; Enzyme-Linked Immunosorbent Assay/veterinary ; Female ; Milk/microbiology ; Retrospective Studies ; United Kingdom
    • Abstract:
      This retrospective case-control study investigates the relationship between seroconversion to Mycobacterium avium subspecies paratuberculosis (MAP) and raised somatic cell count (SCC). The study consists of 112 case cows from three dairy farms in the UK; for each case cow with a positive antibody titre, there was a seronegative control cow for comparison. Seroconversion was monitored using milk ELISA antibody titres for MAP taken at quarterly intervals. SCCs were recorded at the time a positive antibody titre was first recorded as well as at the previous and subsequent milk recording in order to explore a temporal relationship between the two events. The previous and subsequent milk recordings were a month before and after seroconversion was identified. The results showed that cows that were infected with MAP had an increased SCC around the time that they first became seropositive, providing evidence for a temporal relationship between the two events; high SCCs were particularly prevalent before and at the time of first detecting seroconversion. The explanation is being discussed that potentially an underlying, currently not studied, factor may be predisposing both events, the progression of paratuberculosis is predisposing the host to mastitis, or indeed intramammary infections help initiate paratuberculosis progression.
      Competing Interests: Competing interests: None declared.
      (© British Veterinary Association 2019. No commercial re-use. See rights and permissions. Published by BMJ.)
    • Contributed Indexing:
      Keywords: dairy cow; paratuberculosis; seroconversion; subclinical mastitis
    • Publication Date:
      Date Created: 20190727 Date Completed: 20200818 Latest Revision: 20200818
    • Publication Date:
      20221213
    • Accession Number:
      10.1136/vr.104923
    • Accession Number:
      31346134