Improving the Diagnosis of Autism Spectrum Disorder in Fragile X Syndrome by Adapting the Social Communication Questionnaire and the Social Responsiveness Scale-2.

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  • Additional Information
    • Source:
      Publisher: Springer Country of Publication: United States NLM ID: 7904301 Publication Model: Print Cited Medium: Internet ISSN: 1573-3432 (Electronic) Linking ISSN: 01623257 NLM ISO Abbreviation: J Autism Dev Disord Subsets: MEDLINE
    • Publication Information:
      Publication: <2006- >: New York, NY : Springer
      Original Publication: New York, Plenum Press.
    • Subject Terms:
      Communication* ; Interpersonal Relations* ; Surveys and Questionnaires*/standards; Autism Spectrum Disorder/*diagnosis ; Fragile X Syndrome/*diagnosis; Adolescent ; Adult ; Autism Spectrum Disorder/psychology ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Fragile X Syndrome/psychology ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Psychometrics/standards ; Registries ; Social Communication Disorder/diagnosis ; Social Communication Disorder/psychology ; Young Adult
    • Abstract:
      We carried out a psychometric assessment of the Social Communication Questionnaire (SCQ) and the Social Responsiveness Scale (SRS-2) in fragile X syndrome (FXS), relative to clinician DSM5-based diagnosis of autism spectrum disorder (ASD) in FXS. This was followed by instrument revisions that included: removal of non-discriminating and/or low face validity items for FXS; use of receiver operating characteristic (ROC) curves to determine optimal cut points for the original and revised measures; an exploratory factor analysis to outline subscales better representing ASD in FXS; and creation of a "triple criteria" diagnosis to better delineate ASD subgroups in FXS. These methods improved the sensitivity and/or specificity of the SCQ and SRS-2, but diagnostic accuracy of ASD remains problematic in FXS.
    • Grant Information:
      U01 DD001188 United States DD NCBDD CDC HHS; U01DD000231 United States CC CDC HHS; U19DD000753 United States CC CDC HHS; U01DD001189 United States CC CDC HHS
    • Contributed Indexing:
      Keywords: Autism spectrum disorder; Exploratory factor analysis; Fragile X syndrome; Receiver operating characteristic curves; Social Communication Questionnaire; Social Responsiveness Scale-2
    • Publication Date:
      Date Created: 20190726 Date Completed: 20201130 Latest Revision: 20220429
    • Publication Date:
      20240628
    • Accession Number:
      10.1007/s10803-019-04148-0
    • Accession Number:
      31342442