Improvement in Glycemic Control in Mice of Different Age Groups.

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  • Additional Information
    • Source:
      Publisher: J.A. Barth Country of Publication: Germany NLM ID: 9505926 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-3646 (Electronic) Linking ISSN: 09477349 NLM ISO Abbreviation: Exp Clin Endocrinol Diabetes Subsets: MEDLINE
    • Publication Information:
      Original Publication: Heidelberg : J.A. Barth, c1995-
    • Subject Terms:
      Adenoviridae Infections* ; Biological Therapy* ; Blood Glucose*; Aging/*metabolism ; Glucose Intolerance/*blood ; Glucose Intolerance/*therapy ; Insulin/*blood; Age Factors ; Animals ; Disease Models, Animal ; Male ; Mice ; Mice, Inbred C57BL
    • Abstract:
      Aims and Methods: The declining ability to control blood glucose with advancement of age is an important health risk factor and may lead to insulin resistance, type-2-diabetes and Alzheimer's disease. Adenovirus 36(Ad36) improves glycemic control independent of insulin signaling(insulin sparing effect) as evidenced by cell, animal and observational human studies. This property of Ad36 may be useful in correcting aging-related glucose intolerance and related health conditions. Therefore, we determined the effect of Ad36 on glycemic control in older mice, to identify the age group that best responds to Ad36. Six, 12 or 20-month old C57Bl/6 mice on chow diet were each divided into weight-matched groups(mock-infected or Ad36-infected). Body weight was recorded weekly post infection (p.i.) and fasting glucose measured(week 0, 4, 8 and 20 p.i.). Blood glucose and serum insulin were measured during glucose tolerance test(week 0 and 16 p.i.). At week 20 p.i., animals were sacrificed, blood and tissues collected.
      Results: Mice from all age groups showed improvement in glucose clearance post Ad36 infection, but a more profound effect was observed in 6-month old mice compared with mock-infected mice. Under fed conditions though there was no difference in blood glucose at 20 wk p.i., interestingly, Ad36 reduced serum insulin in age groups old mice, compared with control mice.
      Conclusions: These findings suggest Ad36 infected animals improve glycemic control and clear post-prandial gluco00000se increase without increasing insulin secretion in an insulin sparing manner. These beneficial effects provide strong evidence for developing Ad36-based approaches as a novel tool to attenuate age associated glucose intolerance.
      Competing Interests: The authors declare that they have no conflict of interest.
      (Thieme. All rights reserved.)
    • Accession Number:
      0 (Blood Glucose)
      0 (Insulin)
    • Publication Date:
      Date Created: 20190725 Date Completed: 20220114 Latest Revision: 20220114
    • Publication Date:
      20221213
    • Accession Number:
      10.1055/a-0961-7804
    • Accession Number:
      31340394