Association of fasting glucagon-like peptide-1 with oxidative stress and subclinical atherosclerosis in type 2 diabetes.

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  • Additional Information
    • Source:
      Publisher: Elsevier Ltd Country of Publication: Netherlands NLM ID: 101462250 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0334 (Electronic) Linking ISSN: 18714021 NLM ISO Abbreviation: Diabetes Metab Syndr Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam : Elsevier Ltd.
    • Subject Terms:
      Fasting* ; Oxidative Stress*; Atherosclerosis/*etiology ; Biomarkers/*blood ; Diabetes Mellitus, Type 2/*complications ; Glucagon-Like Peptide 1/*blood; Adult ; Aged ; Atherosclerosis/blood ; Atherosclerosis/epidemiology ; Carotid Intima-Media Thickness ; Case-Control Studies ; Cross-Sectional Studies ; Egypt/epidemiology ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Middle Aged ; Prognosis ; Risk Factors
    • Abstract:
      Aim: Glucagon-like peptide-1(GLP-1) is a gut hormone that beside its main function in glucose homeostasis may play a role as an anti-oxidant and anti-atherosclerotic factor. The aim of this study was to estimate fasting total GLP-1 level in type 2 diabetes (T2DM) patients and to determine its relation with oxidative stress and atherosclerotic vascular changes.
      Methods: The study included 60 T2DM male patients with age ≥40 and 30 healthy male subjects matched for age. All of them were subjected to measuring of fasting total GLP-1, 8-iso prostaglandin F2α (8-iso PGF2α) as a marker of oxidative stress and carotid intima media thickness (CIMT) as a marker of subclinical atherosclerosis.
      Results: Fasting total GLP-1 was not significantly different in diabetics in comparison with healthy subjects (p = 0.52). Fasting total GLP-1 was found to have significant negative correlations with both 8-iso PGF2α (p < 0.05) and CIMT (p < 0.001).
      Conclusion: Endogenous fasting GLP-1 appears to have anti-oxidant and anti-atherosclerotic effects in T2DM.
      (Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Atherosclerosis; Glucagon-like peptide-1; Oxidative stress; Type 2 diabetes
    • Accession Number:
      0 (Biomarkers)
      89750-14-1 (Glucagon-Like Peptide 1)
    • Publication Date:
      Date Created: 20190725 Date Completed: 20191227 Latest Revision: 20191227
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.dsx.2019.01.031
    • Accession Number:
      31336447