[Impact of luteal phase support by human chorionic gonadotropin (hCG) in intrauterine inseminations].

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  • Additional Information
    • Transliterated Title:
      Impact du soutien de la phase lutéale par Human Chorionic Gonadotropine (hCG) dans les inséminations intra-utérines.
    • Source:
      Publisher: Elsevier Masson SAS Country of Publication: France NLM ID: 101693805 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-7189 (Electronic) Linking ISSN: 24687189 NLM ISO Abbreviation: Gynecol Obstet Fertil Senol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Issy-les-Moulineaux : Elsevier Masson SAS, [2017]-
    • Subject Terms:
      Chorionic Gonadotropin/*administration & dosage ; Insemination, Artificial/*methods ; Luteal Phase/*drug effects; Adult ; Female ; Follicle Stimulating Hormone/administration & dosage ; France ; Gonadotropin-Releasing Hormone/antagonists & inhibitors ; Humans ; Infertility/therapy ; Luteal Phase/physiology ; Male ; Ovulation Induction/methods ; Pregnancy ; Pregnancy Rate ; Retrospective Studies
    • Abstract:
      Objectives: The objective of our study is to evaluate the impact of luteal phase support by hCG in intrauterine inseminations preceded by ovarian gonadotropin stimulation.
      Methods: A retrospective study was conducted at the CHU of Nice between March 1, 2016 and October 31, 2017. During this period, 300 intrauterine inseminations were included in data analysis. Ovarian stimulation was performed by gonadotropins and a GnRH antagonist was added, if needed. Following a modification of standard operative procedure in the department, patients who performed an intrauterine insemination from December 1, 2016 received luteal phase support with two injections of hCG 1500 IU, performed at three days of interval. Pregnancy and ovarian hyperstimulation syndrome were the primary and secondary study endpoints, respectively.
      Results: Out of 300 inseminations included in the analysis, 144 were performed with luteal phase support and 156 without support. No statistically significant difference in pregnancy rate was observed between these two groups (19.4% of pregnancy in the luteal phase support group and 15.38% in the group without luteal phase support, P=0.353). No ovarian hyperstimulation syndrome occurred over the course of the study.
      Conclusion: Our study shows a slight improvement of pregnancy rate in the group subjected to luteal phase support by hCG after intrauterine insemination, but the benefit was not significant. A randomised prospective study based on a large cohort could help to assess the effect of luteal phase support during intrauterine inseminations.
      (Copyright © 2019 Elsevier Masson SAS. All rights reserved.)
    • Contributed Indexing:
      Keywords: HCG; Inséminations intra-utérines; Intrauterine insemination; Luteal phase; Phase lutéale
    • Accession Number:
      0 (Chorionic Gonadotropin)
      33515-09-2 (Gonadotropin-Releasing Hormone)
      9002-68-0 (Follicle Stimulating Hormone)
    • Publication Date:
      Date Created: 20190724 Date Completed: 20200327 Latest Revision: 20200327
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.gofs.2019.07.008
    • Accession Number:
      31336184