Distinct ipRGC subpopulations mediate light's acute and circadian effects on body temperature and sleep.

Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-

Circadian Rhythm/*genetics ; Retinal Ganglion Cells/*metabolism ; Rod Opsins/*genetics ; Suprachiasmatic Nucleus/*metabolism; Animals ; Body Temperature/genetics ; Brain/metabolism ; Brain/physiology ; Humans ; Mice ; Photoreceptor Cells/metabolism ; Retinal Ganglion Cells/physiology ; Rod Opsins/metabolism ; Sleep/genetics ; Sleep/physiology ; Visual Pathways/metabolism

The light environment greatly impacts human alertness, mood, and cognition by both acute regulation of physiology and indirect alignment of circadian rhythms. These processes require the melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), but the relevant downstream brain areas involved remain elusive. ipRGCs project widely in the brain, including to the central circadian pacemaker, the suprachiasmatic nucleus (SCN). Here we show that body temperature and sleep responses to acute light exposure are absent after genetic ablation of all ipRGCs except a subpopulation that projects to the SCN. Furthermore, by chemogenetic activation of the ipRGCs that avoid the SCN, we show that these cells are sufficient for acute changes in body temperature. Our results challenge the idea that the SCN is a major relay for the acute effects of light on non-image forming behaviors and identify the sensory cells that initiate light's profound effects on body temperature and sleep.
Competing Interests: AR, MR, CA, DF, MR, FT, SH, TS No competing interests declared

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EY024452 United States NH NIH HHS; T32 GM007231 United States GM NIGMS NIH HHS; 1DP2EY027983 United States NH NIH HHS; R21 EY024452 United States EY NEI NIH HHS; DP2 EY027983 United States EY NEI NIH HHS; Fellowship in the Neurosciences International Klingenstein-Simons Fellowship in the Neurosciences; GM076430 United States NH NIH HHS; R01 GM076430 United States GM NIGMS NIH HHS; Research Fellowship in Neuroscience International Sloan Research Fellowship in Neuroscience

Keywords: Suprachiasmatic Nucleus; circadian; ipRGC; melanopsin; mouse; neuroscience; sleep; temperature

0 (Rod Opsins)
0 (melanopsin)

Date Created: 20190724 Date Completed: 20200225 Latest Revision: 20240718

20240718

PMC6650245

10.7554/eLife.44358

31333190