Evaluation of the hypoglycemic effect of seven wild folkloric edible plants from Palestine.

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  • Additional Information
    • Source:
      Publisher: Walter de Gruyter Country of Publication: Germany NLM ID: 101313855 Publication Model: Electronic Cited Medium: Internet ISSN: 1553-3840 (Electronic) Linking ISSN: 15533840 NLM ISO Abbreviation: J Complement Integr Med Subsets: MEDLINE
    • Publication Information:
      Publication: <2012-> : Berlin : Walter de Gruyter
      Original Publication: Berkeley, Calif. : Berkeley Electronic Press, 2004-
    • Subject Terms:
      Hypoglycemic Agents/*pharmacology ; Plant Extracts/*pharmacology ; Plants, Edible/*chemistry ; Plants, Medicinal/*chemistry ; alpha-Amylases/*antagonists & inhibitors; Animals ; Middle East ; Swine
    • Abstract:
      Alfa-amylase inhibitors are used to reduce glucose absorption by suppressing carbohydrate digestion. The current study aimed to evaluate seven wild edible Palestinian plants' hydrophilic and lipophilic fractions against porcine pancreatic α-amylase enzyme. The lipophilic fractions of Arum palaestinum, Malva sylvestris, Plantago major, Centaurea iberica, Cichorium endivia, Bituminaria bituminosa, Sisymbrium irio leaves were sequentially separated with a nonpolar solvent hexane, while the hydrophilic fractions of the studied plants were separated with polar solvents ethanol and water. The activity of α-amylase inhibition was carried out by using α-amylase porcine pancreatic enzyme and 3,5-dinitrosalicylic acid (DNSA) method as well as by using Acarbose as a positive control. Among the studied plant's hydrophilic fractions, C. iberica and C. endivia have the highest porcine pancreatic α-amylase inhibitory effect with an IC50 value of 12.33 µg/mL and 9.96 µg/mL, respectively. In addition, among the studied plant's lipophilic fractions, S. irio and A. palaestinum have the highest porcine pancreatic α-amylase inhibitory effect with an IC50 value of 7.72 µg/mL and 25.3 µg/mL, respectively. In fact, these revealed results were near the values of Acarbose. The hydrophilic fractions of M. sylvestris and the lipophilic fractions of P. major plants exhibit remarkable α-amylase inhibitory activity. Hence, these leaves have a potential for use as regular supplements also; further investigations are required to isolate pure pharmacological molecules and to design suitable pharmaceutical dosage forms with anti-diabetic activity.
    • Contributed Indexing:
      Keywords: Palestine; hydrophilic fraction; lipophilic fraction; wild plants; α-amylase
    • Accession Number:
      0 (Hypoglycemic Agents)
      0 (Plant Extracts)
      EC 3.2.1.1 (alpha-Amylases)
    • Publication Date:
      Date Created: 20190720 Date Completed: 20200608 Latest Revision: 20200608
    • Publication Date:
      20221213
    • Accession Number:
      10.1515/jcim-2019-0032
    • Accession Number:
      31323003