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Decreased Levels of Serum IGF-1 and Vitamin D Are Associated With Cognitive Impairment in Patients With Type 2 Diabetes.
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- Author(s): Rui-Hua C;Rui-Hua C; Yong-de P; Yong-de P; Xiao-Zhen J; Xiao-Zhen J; Chen J; Chen J; Bin Z; Bin Z
- Source:
American journal of Alzheimer's disease and other dementias [Am J Alzheimers Dis Other Demen] 2019 Nov-Dec; Vol. 34 (7-8), pp. 450-456. Date of Electronic Publication: 2019 Jul 18.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Sage Publications Country of Publication: United States NLM ID: 101082834 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-2731 (Electronic) Linking ISSN: 15333175 NLM ISO Abbreviation: Am J Alzheimers Dis Other Demen Subsets: MEDLINE
- Publication Information: Publication: Thousand Oaks, Calif. : Sage Publications
Original Publication: Weston, MA : Prime National Pub. Corp., c2000- - Subject Terms:
- Abstract: Purpose: To determine the association of serum insulin-like growth factor 1 (IGF-1) and vitamin D levels with cognition status in patients with type 2 diabetes mellitus (T2DM).
Methods: A total of 173 patients with T2DM were recruited and divided into mild cognitive impairment (MCI) group (n = 94) and normal cognition (NC) group (n = 79). Levels of IGF-1 and 25(OH)D were measured and compared, and the correlations among IGF-1, 25(OH)D, and cognitive function were analyzed.
Results: Insulin-like growth factor 1 and 25(OH)D levels significantly decreased in MCI group than those in the NC group (both P < .001). Multiple stepwise regression analysis revealed that IGF-1 (β = .146, P < .001) and 25(OH)D (β = .199, P < .001) independently predicted Montreal Cognitive Assessment (MoCA) scores. Partial least square regression showed that contributions of both 25(OH)D ( P < .001) and IGF-1 ( P < .001) to MoCA scores were significant, while no cross-effect was observed between them ( P = .714).
Conclusions: Low serum IGF-1 and 25(OH)D levels may separately predict poor cognitive performance in patients with diabetes. - References: Intern Med J. 2012 May;42(5):484-91. (PMID: 22372522)
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Biomed Res Int. 2013;2013:186106. (PMID: 23936778) - Contributed Indexing: Keywords: IGF-1; Montreal Cognitive Assessment; diabetes mellitus; mental status and dementia tests; mild cognitive impairment; type 2; vitamin D
- Accession Number: 0 (IGF1 protein, human)
67763-96-6 (Insulin-Like Growth Factor I)
P6YZ13C99Q (Calcifediol) - Publication Date: Date Created: 20190720 Date Completed: 20200710 Latest Revision: 20240402
- Publication Date: 20240402
- Accession Number: PMC10653368
- Accession Number: 10.1177/1533317519860334
- Accession Number: 31319676
- Source:
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