Linkage, recombination, and mutation rate analyses of 19 X-chromosomal STR loci in Chinese Southern Han pedigrees.

Publisher: Springer International Country of Publication: Germany NLM ID: 9101456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1437-1596 (Electronic) Linking ISSN: 09379827 NLM ISO Abbreviation: Int J Legal Med Subsets: MEDLINE

Original Publication: Heidelberg, FRG : Springer International, c1990-

Chromosomes, Human, X* ; Genetic Linkage* ; Microsatellite Repeats* ; Mutation Rate* ; Recombination, Genetic*; Ethnicity/*genetics; Asian People/genetics ; China ; Female ; Haplotypes ; Humans ; Likelihood Functions ; Linkage Disequilibrium ; Male ; Pedigree

From Southern Han Chinese samples, we analyzed 19 X-STR markers for linkage, linkage disequilibrium (LD), and mutation rate. The data were collected from two- and three-generation Southern Han Chinese families. These data suggested that both linkage and linkage disequilibrium should be considered while calculating likelihood ratios with X-STR markers in relationship tests. The linkage disequilibrium of these 19 X-STR markers was calculated in our previous research study that was conducted on Southern Han Chinese population. In this study, the recombination fractions between pairs of markers and those obtained from the second-generation Rutgers combined linkage-physical map of the human genome were compared. The observed differences indicated that recombination was not homogeneous along the X chromosome. Therefore, we evaluated the effect on likelihood calculations by referring to haplotype frequencies obtained from allele distributions rather than haplotype counts of Southern Han Chinese population.

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201707010486 Science and Technology Program of Guangzhou, China

Keywords: Han Chinese; Linkage; Linkage disequilibrium; Mutation; X STRs

Date Created: 20190719 Date Completed: 20200402 Latest Revision: 20221207

20221213

10.1007/s00414-019-02121-1

31317316