Laser Light Therapy in Inflammatory, Musculoskeletal, and Autoimmune Disease.

Publisher: Current Science Inc Country of Publication: United States NLM ID: 101096440 Publication Model: Electronic Cited Medium: Internet ISSN: 1534-6315 (Electronic) Linking ISSN: 15297322 NLM ISO Abbreviation: Curr Allergy Asthma Rep Subsets: MEDLINE

Original Publication: Philadelphia, PA : Current Science Inc., c2001-

Autoimmune Diseases/*therapy ; Inflammation/*therapy ; Laser Therapy/*methods ; Low-Level Light Therapy/*methods ; Musculoskeletal Diseases/*therapy; Animals ; Humans

Purpose of Review: The goal of this review is to summarize the field to date and to discuss strengths and limitations of low-level laser (light) therapy (LLLT) for the future investigation as a treatment of inflammatory disease.
Recent Findings: LLLT is a promising therapeutic, particularly for those diseases of skin and joints because they are most accessible to treatment. Indeed, the known mechanisms of LLLT support its use for anti-inflammatory purposes, as well as stimulation of tissue growth and repair. Although the standard of care for the majority of inflammatory diseases is immunosuppressive agents such as corticosteroids with undesirable toxicities, LLLT offers a unique approach by being non-invasive and incurring minimal side effects. It is also relatively inexpensive and accessible and even has the possibility to be patient directed at home. There is evidence that LLLT is able to modulate the immune system at the skin and joint, and it has been shown to be efficacious in humans by affecting bacterial colonization as it may pertain to chronic rhinosinusitis. However, there is variability in the methods of laser application as well as a lack of evidence for laser type, dose-ranging studies, and wavelength selection that create barriers to the implementation of LLLT without further more rigorous and standardized study. The heterogeneity makes it difficult to draw strong conclusions about the efficacy of LLLT and its mechanisms.

Arthritis Rheum. 1999 Aug;42(8):1635-43. (PMID: 10446862)
J Am Acad Dermatol. 2001 May;44(5):755-61. (PMID: 11312420)
Nephrol Dial Transplant. 2001;16 Suppl 5:3-7. (PMID: 11509677)
Dermatol Clin. 2002 Jan;20(1):55-65. (PMID: 11859594)
N Engl J Med. 2002 Jun 13;346(24):1871-7. (PMID: 12063371)
Am J Emerg Med. 2002 Jul;20(4):287-90. (PMID: 12098173)
Arthritis Rheum. 2002 Nov;46(11):2838-46. (PMID: 12428223)
Nat Rev Cancer. 2003 May;3(5):375-80. (PMID: 12724735)
Appl Opt. 2003 Jun 1;42(16):2906-14. (PMID: 12790439)
Int J Dermatol. 2003 Sep;42(9):738-40. (PMID: 12956694)
Otolaryngol Head Neck Surg. 2003 Sep;129(3 Suppl):S1-32. (PMID: 12958561)
Cancer. 2003 Sep 15;98(6):1114-22. (PMID: 12973834)
J Clin Laser Med Surg. 2003 Oct;21(5):283-90. (PMID: 14651796)
Lasers Surg Med. 2003;33(5):296-310. (PMID: 14677157)
J Neurosci. 2004 Jan 28;24(4):964-71. (PMID: 14749441)
Allergy. 2004 Jun;59(6):561-70. (PMID: 15147438)
J Cosmet Laser Ther. 2004 Dec;6(4):191-200. (PMID: 16020203)
Dermatol Ther. 2005 May-Jun;18(3):253-66. (PMID: 16229726)
Br J Dermatol. 2005 Dec;153 Suppl 2:57-62. (PMID: 16280023)
Pathophysiology. 2006 Feb 21;13(1):1-14. (PMID: 16380240)
Arthritis Res Ther. 2006;8(1):R29. (PMID: 16507128)
J Cosmet Laser Ther. 2006 Apr;8(1):27-30. (PMID: 16581682)
Stroke. 2006 Oct;37(10):2620-4. (PMID: 16946145)
Lasers Surg Med. 2007 Feb;39(2):180-8. (PMID: 17111415)
Arthritis Rheum. 2007 Jan;56(1):13-20. (PMID: 17195186)
J Peripher Nerv Syst. 2007 Mar;12(1):28-39. (PMID: 17374099)
Rhinology. 2007 Mar;45(1):3-13. (PMID: 17432062)
J Cosmet Dermatol. 2006 Dec;5(4):274-6. (PMID: 17716243)
Photomed Laser Surg. 2007 Oct;25(5):436-42. (PMID: 17975958)
Am J Med. 2007 Nov;120(11):936-9. (PMID: 17976416)
Lasers Surg Med. 2007 Dec;39(10):797-802. (PMID: 18081143)
J Drugs Dermatol. 2008 Apr;7(4):347-50. (PMID: 18459515)
BMC Microbiol. 2008 Jul 01;8:111. (PMID: 18593460)
J Biomed Sci. 2009 Jan 12;16:4. (PMID: 19272168)
Dermatol Surg. 2009 Apr;35(4):721-3. (PMID: 19400891)
Int J Dermatol. 2010 Jul;49(7):845-7. (PMID: 19627384)
Photomed Laser Surg. 2010 Feb;28(1):141-6. (PMID: 19764893)
Ann Allergy Asthma Immunol. 2009 Nov;103(5):436-41. (PMID: 19927544)
N Engl J Med. 2010 Jan 7;362(1):9-17. (PMID: 20054045)
J Steroid Biochem Mol Biol. 2010 May 31;120(2-3):76-85. (PMID: 20188830)
Drug Discov Today. 2010 Jun;15(11-12):468-73. (PMID: 20450983)
J Immunol. 2010 Jul 15;185(2):884-91. (PMID: 20562264)
IUBMB Life. 2010 Aug;62(8):607-10. (PMID: 20681024)
Mol Membr Biol. 2010 Oct;27(7):364-81. (PMID: 20939770)
Biomaterials. 2011 Feb;32(5):1377-86. (PMID: 21074848)
J Alzheimers Dis. 2011;23(3):521-35. (PMID: 21116053)
Lasers Surg Med. 2011 Mar;43(3):187-91. (PMID: 21290392)
Discov Med. 2011 Feb;11(57):154-9. (PMID: 21356170)
Lasers Med Sci. 2011 Sep;26(5):707-17. (PMID: 21541773)
J Allergy Clin Immunol. 2011 Aug;128(2):397-402.e2. (PMID: 21683432)
PLoS One. 2011;6(7):e22453. (PMID: 21814580)
Allergy Asthma Immunol Res. 2011 Oct;3(4):226-35. (PMID: 21966602)
PLoS One. 2011;6(10):e26377. (PMID: 22039475)
J Neurotrauma. 2012 Jan 20;29(2):401-7. (PMID: 22040267)
Ann Biomed Eng. 2012 Feb;40(2):516-33. (PMID: 22045511)
Dermatology. 2011;223(3):251-9. (PMID: 22105015)
Cytokine. 2012 Apr;58(1):20-6. (PMID: 22249152)
J Am Acad Dermatol. 2012 Apr;66(4):553-62. (PMID: 22264671)
Am J Otolaryngol. 2012 Sep-Oct;33(5):572-5. (PMID: 22503099)
Lasers Med Sci. 2013 Feb;28(2):529-36. (PMID: 22538842)
PLoS One. 2012;7(10):e47460. (PMID: 23077622)
J Am Vet Med Assoc. 2012 Nov 15;241(10):1314-9. (PMID: 23113523)
Lasers Med Sci. 2013 Jul;28(4):1189-96. (PMID: 23139073)
PLoS One. 2013;8(1):e53454. (PMID: 23308226)
Physiother Theory Pract. 2013 Nov;29(8):596-603. (PMID: 23521568)
Neuroimage. 2014 Jan 15;85 Pt 1:136-49. (PMID: 23660029)
Anticancer Res. 2013 Jul;33(7):2823-31. (PMID: 23780966)
Acta Med Iran. 2013 Sep 09;51(8):543-7. (PMID: 24026991)
Semin Cutan Med Surg. 2013 Mar;32(1):41-52. (PMID: 24049929)
Lasers Med Sci. 2014 May;29(3):1043-50. (PMID: 24158722)
Angew Chem Int Ed Engl. 2014 Jan 13;53(3):875-8. (PMID: 24285381)
J Photochem Photobiol B. 2014 Jan 5;130:327-36. (PMID: 24419178)
Respir Physiol Neurobiol. 2014 Apr 1;194:37-48. (PMID: 24486607)
J Drugs Dermatol. 2014 May;13(5):564-8. (PMID: 24809879)
Photomed Laser Surg. 2014 Jun;32(6):336-44. (PMID: 24905929)
Vet Dermatol. 2014 Oct;25(5):464-e74. (PMID: 24909192)
J Mol Neurosci. 2015 Feb;55(2):430-6. (PMID: 24994540)
J Dent Res Dent Clin Dent Prospects. 2014 Winter;8(1):1-5. (PMID: 25024832)
Lasers Surg Med. 2014 Oct;46(8):601-7. (PMID: 25124964)
Anesth Pain Med. 2014 Jun 21;4(3):e17350. (PMID: 25237637)
Actas Dermosifiliogr. 2015 Apr;106(3):158-67. (PMID: 25444580)
Lasers Surg Med. 2015 Apr;47(4):312-22. (PMID: 25772014)
Phys Med Biol. 2015 Apr 7;60(7):2921-37. (PMID: 25789711)
PLoS One. 2015 Jun 03;10(6):e0127580. (PMID: 26039354)
Neuropsychiatr Dis Treat. 2015 Aug 21;11:2191-208. (PMID: 26346298)
Acc Chem Res. 2015 Nov 17;48(11):2866-74. (PMID: 26479305)
Autoimmunity. 2016;49(2):132-42. (PMID: 26703077)
MOJ Orthop Rheumatol. 2015;2(5):null. (PMID: 26858986)
Semin Neurol. 2016 Apr;36(2):115-27. (PMID: 27116718)
J Cosmet Laser Ther. 2017 Apr;19(2):93-99. (PMID: 27802065)
Nat Rev Dis Primers. 2016 Nov 24;2:16082. (PMID: 27883001)
IEEE J Sel Top Quantum Electron. 2016 May-Jun;22(3):. (PMID: 28070154)
Eur J Phys Rehabil Med. 2017 Aug;53(4):603-610. (PMID: 28145397)
Lasers Med Sci. 2017 Aug;32(6):1269-1277. (PMID: 28560473)
Lasers Med Sci. 2017 Aug;32(6):1439-1448. (PMID: 28580494)
Altern Ther Health Med. 2018 Sep;24(5):8-10. (PMID: 28987080)
Lasers Med Sci. 2018 Jan;33(1):173-180. (PMID: 29067616)
Lasers Med Sci. 2018 Feb;33(2):435-444. (PMID: 29250710)
J Biophotonics. 2019 Jan;12(1):e201800092. (PMID: 29885019)
Photodiagnosis Photodyn Ther. 2018 Dec;24:82-87. (PMID: 30118905)
Mol Immunol. 2019 Feb;106:12-21. (PMID: 30576947)
Photochem Photobiol Sci. 2019 May 15;18(5):1020-1029. (PMID: 30821303)
Radiobiol Radiother (Berl). 1968;9(5):621-6. (PMID: 5732466)
Arch Dermatol. 1981 Aug;117(8):465-8. (PMID: 7259240)
Virchows Arch. 1994;424(5):459-64. (PMID: 8032526)
Rheumatol Int. 1993;13(2):45-51. (PMID: 8356390)
Ann Rheum Dis. 1993 Mar;52(3):232-4. (PMID: 8484679)
Acad Emerg Med. 1996 Feb;3(2):142-6. (PMID: 8808375)
Nephrol Dial Transplant. 1997 Jun;12(6):1109-15. (PMID: 9198037)
J Am Soc Nephrol. 1997 Nov;8(11):1712-21. (PMID: 9355074)

T32 CA071341 United States CA NCI NIH HHS

Keywords: Autoimmunity; Inflammatory disease; Low-level light/laser; Photodynamic therapy; Phototherapeutics; Phototherapy

Date Created: 20190704 Date Completed: 20200421 Latest Revision: 20200714

20240628

PMC7357616

10.1007/s11882-019-0869-z

31267251