Garlic Consumption and All-Cause Mortality among Chinese Oldest-Old Individuals: A Population-Based Cohort Study.

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  • Additional Information
    • Source:
      Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI Publishing
    • Subject Terms:
      Asian People* ; Garlic* ; Plant Roots*; Aging/*ethnology; Age Factors ; Aged, 80 and over ; Cause of Death ; China/epidemiology ; Female ; Health Status ; Humans ; Longevity ; Longitudinal Studies ; Male ; Middle Aged ; Nutritive Value ; Protective Factors ; Risk Factors ; Time Factors
    • Abstract:
      In vitro and in vivo experimental studies have shown garlic has protective effects on the aging process; however, there is no evidence that garlic consumption is associated with all-cause mortality among oldest-old individuals (≥80 years). From 1998 to 2011, 27,437 oldest-old participants (mean age: 92.9 years) were recruited from 23 provinces in China. The frequencies of garlic consumption at baseline and at age 60 were collected. Cox proportional hazards models adjusted for potential covariates were constructed to estimate hazard ratios (HRs) relating garlic consumption to all-cause mortality. Among 92,505 person-years of follow-up from baseline to September 1, 2014, 22,321 participants died. Participants who often (≥5 times/week) or occasionally (1-4 times/week) consumed garlic survived longer than those who rarely (less than once/week) consumed it ( p < 0.001). Participants who consumed garlic occasionally or often had a lower risk for mortality than those who rarely consumed garlic at baseline; the adjusted HRs for mortality were 0.92(0.89-0.94) and 0.89(0.85-0.92), respectively. The inverse associations between garlic consumption and all-cause mortality were robust in sensitivity analyses and subgroup analyses. In this study, habitual consumption of garlic was associated with a lower all-cause mortality risk; this advocates further investigation into garlic consumption for promoting longevity.
      Competing Interests: The authors declare no conflict of interest.
    • References:
      J Nutr Health Aging. 1998;2(2):84-7. (PMID: 10993571)
      J Nutr. 2001 Mar;131(3s):1020S-6S. (PMID: 11238809)
      J Nutr. 2001 Mar;131(3s):1054S-7S. (PMID: 11238815)
      J Gerontol A Biol Sci Med Sci. 2001 Nov;56(11):M714-8. (PMID: 11682580)
      Appl Microbiol Biotechnol. 2001 Oct;57(3):282-6. (PMID: 11759674)
      Res Nurs Health. 2002 Feb;25(1):76-84. (PMID: 11807922)
      J Psychiatr Res. 1975 Nov;12(3):189-98. (PMID: 1202204)
      Ageing Res Rev. 2003 Jan;2(1):39-56. (PMID: 12437995)
      Free Radic Biol Med. 2003 Aug 1;35(3):317-24. (PMID: 12885594)
      J Gerontol. 1956 Jul;11(3):298-300. (PMID: 13332224)
      JAMA. 1963 Sep 21;185:914-9. (PMID: 14044222)
      Chin Med J (Engl). 2004 Aug;117(8):1155-60. (PMID: 15361287)
      Crit Rev Food Sci Nutr. 2004;44(6):479-88. (PMID: 15615431)
      J Gerontol B Psychol Sci Soc Sci. 2006 Mar;61(2):S107-15. (PMID: 16497961)
      Mol Nutr Food Res. 2007 Nov;51(11):1386-97. (PMID: 17918162)
      BMC Cardiovasc Disord. 2008 Jun 16;8:13. (PMID: 18554422)
      Am J Clin Nutr. 2009 Jan;89(1):257-64. (PMID: 19056580)
      Prev Med. 2009 Aug-Sep;49(2-3):101-7. (PMID: 19573556)
      Br J Nutr. 2012 Nov 14;108(9):1686-97. (PMID: 22243697)
      Cochrane Database Syst Rev. 2012 Aug 15;(8):CD007653. (PMID: 22895963)
      Crit Rev Food Sci Nutr. 2013;53(3):215-30. (PMID: 23215996)
      Molecules. 2013 Jan 04;18(1):690-700. (PMID: 23292331)
      Cancer Prev Res (Phila). 2013 Jul;6(7):711-8. (PMID: 23658367)
      Nutr Res. 2014 Feb;34(2):106-15. (PMID: 24461311)
      Nutr Res Rev. 2011 Jun;24(1):60-71. (PMID: 24725925)
      Arch Gerontol Geriatr. 2014 Sep-Oct;59(2):227-33. (PMID: 25063588)
      Appetite. 2014 Dec;83:89-96. (PMID: 25131903)
      Mol Nutr Food Res. 2015 Jan;59(1):171-9. (PMID: 25215621)
      Nutr Cancer. 2015;67(1):1-11. (PMID: 25411831)
      Oxid Med Cell Longev. 2015;2015:504678. (PMID: 26301043)
      Nutrients. 2015 Sep 09;7(9):7562-79. (PMID: 26371039)
      Phytomedicine. 2016 Oct 15;23(11):1127-33. (PMID: 26656227)
      J Nutr. 2016 Feb;146(2):433S-436S. (PMID: 26764332)
      Cancer Epidemiol Biomarkers Prev. 2016 Apr;25(4):624-33. (PMID: 26809277)
      Food Chem. 2016 Nov 15;211:41-50. (PMID: 27283605)
      J Gerontol B Psychol Sci Soc Sci. 2019 Feb 15;74(3):474-483. (PMID: 28184889)
      Lancet. 2017 Apr 22;389(10079):1619-1629. (PMID: 28285816)
      Nutrition. 2017 Nov - Dec;43-44:89-97. (PMID: 28935151)
      J Nutr Health Aging. 2017;21(10):1089-1094. (PMID: 29188865)
      Nutrients. 2018 Apr 05;10(4):null. (PMID: 29621132)
      Nutrients. 2018 Dec 23;11(1):null. (PMID: 30583613)
      JAMA Netw Open. 2018 Sep 7;1(5):e181915. (PMID: 30646143)
      Nutrients. 2019 Jan 30;11(2):null. (PMID: 30704060)
      Cancer Res. 1994 Dec 1;54(23):6148-53. (PMID: 7954460)
    • Grant Information:
      81273160 National Natural Science Foundation of China; 81573247 National Natural Science Foundation of China
    • Contributed Indexing:
      Keywords: elderly; garlic; mortality; oldest old; survival
    • Publication Date:
      Date Created: 20190703 Date Completed: 20200107 Latest Revision: 20221207
    • Publication Date:
      20231215
    • Accession Number:
      PMC6683033
    • Accession Number:
      10.3390/nu11071504
    • Accession Number:
      31262080