[Effects of a 12-week high intensity interval training on blood lipid of dyslipidemia patients with different apolipoprotein E genotypes].

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  • Author(s): He YY;He YY; Wang WR; Wang WR
  • Source:
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology [Zhongguo Ying Yong Sheng Li Xue Za Zhi] 2019 Jan; Vol. 35 (1), pp. 28-33.
  • Publication Type:
    Journal Article
  • Language:
    Chinese
  • Additional Information
    • Source:
      Publisher: Zhongguo ying yong sheng li xue za zhi bian ji bu Country of Publication: China NLM ID: 9426407 Publication Model: Print Cited Medium: Print ISSN: 1000-6834 (Print) Linking ISSN: 10006834 NLM ISO Abbreviation: Zhongguo Ying Yong Sheng Li Xue Za Zhi Subsets: MEDLINE
    • Publication Information:
      Publication: Tianjin : Zhongguo ying yong sheng li xue za zhi bian ji bu
      Original Publication: Beijing Shi : Zhongguo ying yong sheng li xue za zhi bian ji bu,
    • Subject Terms:
      Apolipoproteins E*/genetics ; Dyslipidemias*/genetics ; Dyslipidemias*/therapy ; High-Intensity Interval Training* ; Lipids*/blood; Genotype ; Humans
    • Abstract:
      Objective: To evaluate the effects of 12 weeks high intensity interval training(HIIT) on serum lipids profile in patients with dyslipidemia of different apolipoprotein E(ApoE) genotypes.
      Methods: Eighty-eight patients with dyslipidemia were screened by fasting blood lipid as subjects. Apolipoprotein E genotypes were detected in oral mucosa of subjects. Serum lipids before and after 12 weeks high intensity interval training were measured to analysis the effect of high intensity interval training on serum lipids.
      Results: Five genotypes were detected in 88 cases of dyslipidemia. The distributions were ApoE3/3＞ApoE3/4＞ApoE2/3＞ApoE2/2＞ApoE2/4,and allele ε3＞ε2=ε4. Before exercise intervention, the level of total cholesterol in patients with ε4 allele was significant higher than those in patients with ε2 and ε3 (P＜0.01), low density lipoprotein cholesterol in patients with ε4 was significant higher than that of patients with ε2 (P＜0.05), and the other indexes had no significant difference among the groups (P＞ 0.05). After 12 weeks high intensity interval training, the levels of total cholesterol, triglyceride and low density lipoprotein cholesterol were decreased significantly ,while the level of high density lipoprotein cholesterol was increased in those patients with ε3 genotype. For those individuals with ε4 genotype , their serum levels of total cholesterol and low density lipoprotein cholesterol were reduced after 12 weeks high intensity interval training , but there was no changes in serum levels of triglyceride and high density lipoprotein cholesterol. For those individuals with ε2 genotype, there was no significant improvement in serum lipids after 12 weeks high intensity interval training interventions.
      Conclusion: The polymorphisms of apolipoprotein E gene resulted in different effects of exercise interventions on serum lipids of dyslipidemia. Twelve weeks high intensity interval training can be used as an intervention method to regulate serum lipids of dyslipidemia with ε3 and ε4 alleles.
    • Accession Number:
      0 (Apolipoproteins E)
      0 (Lipids)
    • Publication Date:
      Date Created: 20190628 Date Completed: 20190905 Latest Revision: 20190906
    • Publication Date:
      20240829
    • Accession Number:
      10.12047/j.cjap.5749.2019.007
    • Accession Number:
      31245949