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Limfocyty regulatorowe.
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- Author(s): Jagła, Mateusz ; Cichocka-Jarosz, Ewa
- Source:
Alergia Astma Immunologia. 2007, Vol. 12 Issue 3, p22-29. 8p. 4 Diagrams, 2 Charts.- Subject Terms:
- Source:
- Additional Information
- Alternate Title: Regulatory T Cells.
- Abstract: Regulatory T cells (Treg) are a phenotypic diverse group of cells responsible for controlling the function of the immune system. These cells are responsible for regulation of immune response and play a leading role in developing immune tolerance through active suppression. To-date, several subtypes of regulatory lymphocytes have been described, the most important of them being CD4+CD25+, NK Th1 lymphocytes and Tr3 cells. The mechanism, by which regulatory T cells function is dependent on the release of suppressive cytokine (IL-10, TGF-β) or is mediated by cell-to-cell interaction via suppressive surface molecules. Abnormalities in the function of regulatory T cells are important in pathogenesis of numerous autoimmune, allergic and chronic infectious diseases both in animal and human studies. Gaining a full undestanding of these cells will be helpful in explaining mechanisms important in controlling the immune system activity, and the immunologic or pharmacologic modification of thier functions may be useful in the future as a new approach to immunotheraphy. The objective of this review is to clarify the physiology of regulatory cells, explain their role in various immunologic diseases and show future perspectives for their clinical application. [ABSTRACT FROM AUTHOR]
- Abstract: Limfocyty regulatorowe (Treg) są niejednorodną fetotypowo grupą komórek odpowiedzialną za kontrolę funkcji układu immunologicznego. Komórki te odpowiadają za regulację odpowiedzi immunologicznej i odgrywają fundamentalną rolę w procesach nabywania tolerancji immunologicznej na drodze aktywnej supresji. Dotychczas wyodrębniono kilka subpopulacji komórek regulatorowych, z których do najważniejszych należą limfocyty CD4+CD25, limpocyty NK oraz limfocyty Th1 i Tr3. Mechanizm dzialania komórek regulatorowych opiera się o uwalniane cytokin o działaniu supresorowym (IL-10, TGF-β) bądż zachodzi na drodze bezpośredniego oddziaływania z komórką docelową poprzez prezentację na ich powierzchni cząstek supresyjnych. Zaburzenia dzialania Treg odgrywają istotne w patogenezie licznych chorób autoimmunologicznych, alergicznych czy przewlekłych zakażeń zarówno w modelach zwierzęcych, jak i u człowieka. Pełne poznanie i zrozumienie mechanizmów działania tych komórek w istotny sposób wyjaśb mechanizmy kontroli aktywności układu immunologicznego, a farmakologiczna bądż immunologiczna modyfikacja ich funkcji, mogłaby w przyszłości posłużyć jako forma immunoterapii. Celem poniższego opracowania jest przedstawienie aktualnego stanu wiedzy o mechanizmach działania limfocytów regulatorowych, ich znaczeniu w różnorodnych zaburzeniach immunologicznych oraz przyszłych perspektywach ich klinicznego zastosowania. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Alergia Astma Immunologia is the property of Alergia Astma Immunologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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