The detection of house dust mite Dermatophagoides farinae, Der f 2 and Zen-1 allergen-specific immunoglobulin E antibodies in dogs with atopic Dermatitis in Malaysia.

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  • Additional Information
    • Source:
      Publisher: Elsevier Scientific Country of Publication: Netherlands NLM ID: 8002006 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2534 (Electronic) Linking ISSN: 01652427 NLM ISO Abbreviation: Vet Immunol Immunopathol
    • Publication Information:
      Original Publication: [Amsterdam] Elsevier Scientific.
    • Subject Terms:
      Antigens, Dermatophagoides/*immunology ; Arthropod Proteins/*immunology ; Dermatitis, Atopic/*veterinary ; Dog Diseases/*immunology ; Immunoglobulin E/*blood; Allergens/immunology ; Animals ; Antigens, Dermatophagoides/blood ; Arthropod Proteins/blood ; Dermatitis, Atopic/immunology ; Dermatitis, Atopic/parasitology ; Dermatophagoides farinae ; Dog Diseases/parasitology ; Dogs ; Enzyme-Linked Immunosorbent Assay ; Hospitals, Animal ; Malaysia ; Pets/immunology
    • Abstract:
      Canine atopic dermatitis (AD) is a chronic, inflammatory and pruritic allergic skin disease in dogs. House dust mites such as Dermatophagoides farinae are one of the known causative agents for the induction of canine AD worldwide. D. farinae protein Der f 2 is known as an important allergen involved in canine AD and recently, Zen-1 has also been identified as an allergenic protein. There is limited information on the prevalence and role of allergen sensitization to crude D. farinae extract (CDF), Der f 2 and Zen-1 among dogs diagnosed with AD in Malaysia. The aim of this study was to determine the proportion of CDF-, Der f 2- and Zen-1-specific reactive sera among dogs diagnosed with AD in Malaysia using an enzyme-linked immunosorbent assay (ELISA). Serum samples were collected from dogs diagnosed with AD from several veterinary clinics in Malaysia. The canine case records were retrieved and information on signalment, dermatological and non-dermatological histories, clinical presentation, food allergies, and exclusion of ectoparasitic, microbial and fungal skin infections were obtained through a survey form. All serum samples were evaluated to quantify the CDF-, Der f 2- and Zen-1-specific immunoglobulin E (IgE) levels. A total of 24.6%, 48.4% and 29.8% of dogs diagnosed with AD were positive for CDF-, Der f 2- and Zen-1-specific IgE, respectively. These results suggest that CDF-, Der f 2- and Zen-1 are important allergens that can contribute to AD in dogs in Malaysia, and serological testing can be performed to provide additional treatment options involving specific immunotherapies.
      (Copyright © 2019 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Atopic dermatitis; CDF; Der f 2; Dogs; Dust mites; IgE; Zen-1
    • Accession Number:
      0 (Allergens)
      0 (Antigens, Dermatophagoides)
      0 (Arthropod Proteins)
      0 (Dermatophagoides farinae antigen f 2)
      37341-29-0 (Immunoglobulin E)
    • Publication Date:
      Date Created: 20190620 Date Completed: 20190808 Latest Revision: 20190808
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.vetimm.2019.05.002
    • Accession Number:
      31213251