Characterizing mechanical and medical imaging properties of polyvinyl chloride-based tissue-mimicking materials.

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  • Additional Information
    • Source:
      Publisher: Wiley on behalf of American Association of Physicists in Medicine Country of Publication: United States NLM ID: 101089176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-9914 (Electronic) Linking ISSN: 15269914 NLM ISO Abbreviation: J Appl Clin Med Phys Subsets: MEDLINE
    • Publication Information:
      Publication: 2017- : Malden, MA : Wiley on behalf of American Association of Physicists in Medicine
      Original Publication: Reston, VA : American College of Medical Physics, c2000-
    • Subject Terms:
      Phantoms, Imaging* ; Radiography, Thoracic*; Image Processing, Computer-Assisted/*methods ; Magnetic Resonance Imaging/*methods ; Multimodal Imaging/*instrumentation ; Polyvinyl Chloride/*chemistry ; Tomography, X-Ray Computed/*methods; Humans ; Magnetic Resonance Imaging/instrumentation ; Tomography, X-Ray Computed/instrumentation
    • Abstract:
      Polyvinyl chloride (PVC) is a commonly used tissue-mimicking material (TMM) for phantom construction using 3D printing technology. PVC-based TMMs consist of a mixture of PVC powder and dioctyl terephthalate as a softener. In order to allow the clinical use of a PVC-based phantom use across CT and magnetic resonance imaging (MRI) imaging platforms, we evaluated the mechanical and physical imaging characteristics of ten PVC samples. The samples were made with different PVC-softener ratios to optimize phantom bioequivalence with physiologic human tissue. Phantom imaging characteristics, including computed tomography (CT) number, MRI relaxation time, and mechanical properties (e.g., Poisson's ratio and elastic modulus) were quantified. CT number varied over a range of approximately -10 to 110 HU. The relaxation times of the T1-weighted and T2-weighted images were 206.81 ± 17.50 and 20.22 ± 5.74 ms, respectively. Tensile testing was performed to evaluate mechanical properties on the three PVC samples that were closest to human tissue. The elastic moduli for these samples ranged 7.000-12.376 MPa, and Poisson's ratios were 0.604-0.644. After physical and imaging characterization of the various PVC-based phantoms, we successfully produced a bioequivalent phantom compatible with multimodal imaging platforms for machine calibration and image optimization/benchmarking. By combining PVC with 3D printing technologies, it is possible to construct imaging phantoms simulating human anatomies with tissue equivalency.
      (© 2019 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.)
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    • Grant Information:
      2016YFC0103400 China National Key Research and Development Program; 2017GSF218075 Shandong Province Key Research and Development Program; TS201712065 Taishan Scholars Program of Shandong Province
    • Contributed Indexing:
      Keywords: 3D printing; elastic modulus; multimodality; phantom; polyvinyl chloride
    • Accession Number:
      9002-86-2 (Polyvinyl Chloride)
    • Publication Date:
      Date Created: 20190618 Date Completed: 20191220 Latest Revision: 20200225
    • Publication Date:
      20221213
    • Accession Number:
      PMC6612694
    • Accession Number:
      10.1002/acm2.12661
    • Accession Number:
      31207035