Toxicity mechanisms of ZnO UV-filters used in sunscreens toward the model cyanobacteria Synechococcus elongatus PCC 7942.

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  • Additional Information
    • Source:
      Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE
    • Publication Information:
      Publication: <2013->: Berlin : Springer
      Original Publication: Landsberg, Germany : Ecomed
    • Subject Terms:
      Cyanobacteria/*drug effects ; Nanoparticles/*toxicity ; Synechococcus/*chemistry ; Zinc Oxide/*chemistry; Adsorption ; Cyanobacteria/chemistry ; DNA Damage ; Ecosystem ; Oxidative Stress ; Photosynthesis ; Sunscreening Agents/chemistry ; Zinc Oxide/toxicity
    • Abstract:
      Zinc oxide (ZnO) nanoparticles are commonly used in sunscreens for their UV-filtering properties. Their growing use can lead to their release into ecosystems, raising question about their toxicity. Effects of these engineered nanomaterials (ENMs) on cyanobacteria, which are important primary producers involved in many biogeochemical cycles, are unknown. In this study, we investigated by several complementary approaches the toxicological effects of two marketed ZnO-ENMs (coated and uncoated) on the model cyanobacteria Synechococcus elongatus PCC 7942. It was shown that despite the rapid adsorption of ENMs on cell surface, toxicity is mainly due to labile Zn released by ENMs. Zn dissipates cell membrane potential necessary for both photosynthesis and respiration, and induces oxidative stress leading to lipid peroxidation and DNA damages. It leads to global downregulation of photosystems, oxidative phosphorylation, and transcription/translation machineries. This also translates into significant decrease of intracellular ATP content and cell growth inhibition. However, there is no major loss of pigments and even rather an increase in exposed cells compared to controls. A proposed way to reduce the environmental impact of Zn would be the improvement of the coating stability to prevent solubility of ZnO-ENMs.
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    • Grant Information:
      ANR P2N Mesonnet Agence Nationale pour la Recherche
    • Contributed Indexing:
      Keywords: Cyanobacteria; Nanomaterial; Sunscreen; Transcriptomic; Zinc oxide
    • Accession Number:
      0 (Sunscreening Agents)
      SOI2LOH54Z (Zinc Oxide)
    • Publication Date:
      Date Created: 20190605 Date Completed: 20191007 Latest Revision: 20200225
    • Publication Date:
      20240829
    • Accession Number:
      10.1007/s11356-019-05057-6
    • Accession Number:
      31161548