Genotoxicity and carcinogenicity of ivermectin and amoxicillin in vivo systems.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9612020 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7077 (Electronic) Linking ISSN: 13826689 NLM ISO Abbreviation: Environ Toxicol Pharmacol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam : Elsevier Science B.V., c1996-
    • Subject Terms:
      Amoxicillin/*toxicity ; Antiparasitic Agents/*toxicity ; Carcinogens/*toxicity ; Ivermectin/*toxicity ; Mutagens/*toxicity; Animals ; Carcinoma/chemically induced ; DNA Damage ; Drosophila melanogaster/drug effects ; Drosophila melanogaster/genetics ; Female ; Larva/drug effects ; Larva/genetics ; Male ; Mutagenicity Tests ; Tradescantia/drug effects ; Tradescantia/genetics
    • Abstract:
      Antiparasitic substances are chemicals used to control or kill endoparasites and ectoparasites. Based on the premise that Ivermectin (IVM) and Amoxicillin (AMX) are commonly considered in parasitic control in mammals, the present study aimed to evaluate the carcinogenic and genotoxic potential of different concentrations of IVM and AMX through the detection of epithelial tumor test in Drosophila melanogaster. Third-instar larvae descending from the cross between wts/TM3, Sb 1 females and mwh/mwh males were treated with different concentrations of IVM (2.9, 5.8, 11.6 and 23.2 x 10 -17 mM) or AMX (1.37, 2.74, 5.48 and 10.9 x 10 -16 mM). The results revealed that IVM increased the frequency of epithelial tumor in D. melanogaster considering all evaluated concentrations, while AMX showed no carcinogenic effect. Furthermore, the Micronucleus (MN) test in Tradescantia pallida was used to evaluate the genotoxic effect of IVM and AMX. T. pallida individuals were exposed for 8 hours at different concentrations of IVM (5.71, 11.42, 22.84 and 45.68 x 10 -5 mM) or AMX (5.13, 10.26, 20.52 and 41.05 x 10 -3 mM). Findings showed an increase in the frequency of micronuclei in T. pallida treated with 11.42, 22.84 and 45.68 x 10 -5 mM of IVM. We conclude that chronic exposure to IVM is directly associated with events resulting from genetic instability (genotoxicity and carcinogenicity). On the other hand, AMX was neither carcinogenic nor genotoxic for D. melanogaster and T. pallida.
      (Copyright © 2019 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Antiparasitic substances; Epithelial tumor; Micronucleus; Mutagenicity
    • Accession Number:
      0 (Antiparasitic Agents)
      0 (Carcinogens)
      0 (Mutagens)
      70288-86-7 (Ivermectin)
      804826J2HU (Amoxicillin)
    • Publication Date:
      Date Created: 20190602 Date Completed: 20200110 Latest Revision: 20200110
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.etap.2019.103196
    • Accession Number:
      31152944