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Differential Anti-Adipogenic Effects of Eicosapentaenoic and Docosahexaenoic Acids in Obesity.
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- Author(s): Zhuang P;Zhuang P; Lu Y; Lu Y; Shou Q; Shou Q; Mao L; Mao L; He L; He L; Wang J; Wang J; Chen J; Chen J; Zhang Y; Zhang Y; Jiao J; Jiao J
- Source:
Molecular nutrition & food research [Mol Nutr Food Res] 2019 Jul; Vol. 63 (14), pp. e1801135. Date of Electronic Publication: 2019 Jun 12.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101231818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-4133 (Electronic) Linking ISSN: 16134125 NLM ISO Abbreviation: Mol Nutr Food Res Subsets: MEDLINE
- Publication Information: Original Publication: Weinheim, Germany : Wiley-VCH, c2004-
- Subject Terms: Adipogenesis/*physiology ; Docosahexaenoic Acids/*blood ; Eicosapentaenoic Acid/*blood ; Obesity/*blood; 3T3-L1 Cells ; Adipogenesis/drug effects ; Adipose Tissue, White/drug effects ; Adipose Tissue, White/physiology ; Animals ; Anti-Obesity Agents/pharmacology ; Body Fat Distribution ; Diet, High-Fat/adverse effects ; Dietary Supplements ; Docosahexaenoic Acids/pharmacology ; Eicosapentaenoic Acid/pharmacology ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Nutrition Surveys ; Obesity/etiology ; United States
- Abstract: Scope: To assess the associations of plasma eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) with body fat in a population-based sample and explore the mechanism of action based on browning of white adipose tissue (WAT) in high-fat-diet-induced obese (DIO) mice and 3T3-L1 adipocytes.
Methods and Results: Plasma EPA and DHA of 1719 adults in the National Health and Nutrition Examination Survey (2003-2004) are determined by gas chromatography mass spectrometry, while total body fat is measured by dual-energy X-ray absorptiometry. DIO mice are fed a high-fat diet supplemented with EPA or DHA (1% wt/wt) for 15 weeks and 3T3-L1 preadipocytes are treated with EPA or DHA during differentiation. Plasma DHA but not EPA is associated with lower body fat mass (ptrend < 0.0001), which persists in overweight/obese subjects (ptrend = 0.02). DHA supplementation reduces inguinal WAT and exhibits a more pronounced thermogenic effect than EPA in DIO mice. In vitro, the browning process is induced after 2-day and 6-day treatment with DHA and EPA, respectively.
Conclusion: Plasma DHA but not EPA is inversely associated with body fat mass. The more potent anti-adipogenic effect of DHA than EPA may involve a better capability of inducing browning of WAT for DHA.
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- Accession Number: 0 (Anti-Obesity Agents)
25167-62-8 (Docosahexaenoic Acids)
AAN7QOV9EA (Eicosapentaenoic Acid) - Publication Date: Date Created: 20190530 Date Completed: 20201113 Latest Revision: 20201113
- Publication Date: 20221213
- Accession Number: 10.1002/mnfr.201801135
- Accession Number: 31140724
- Source:
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