G-CSF enhances the therapeutic potency of stem cells transplantation in spinal cord-injured rats.

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  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 101278116 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1746-076X (Electronic) Linking ISSN: 17460751 NLM ISO Abbreviation: Regen Med Subsets: MEDLINE
    • Publication Information:
      Publication: 2024- : [Milton Park, Oxfordshire] : Taylor & Francis
      Original Publication: London, UK : Future Medicine Ltd., c2006-
    • Subject Terms:
      Neural Stem Cells*/metabolism ; Neural Stem Cells*/pathology ; Neural Stem Cells*/transplantation ; Spinal Cord Injuries*/metabolism ; Spinal Cord Injuries*/pathology ; Spinal Cord Injuries*/physiopathology ; Spinal Cord Injuries*/therapy ; Stem Cell Transplantation*; Granulocyte Colony-Stimulating Factor/*pharmacology; Animals ; Heterografts ; Humans ; Male ; Rats ; Rats, Long-Evans
    • Abstract:
      Aim: The therapeutic effects of human wisdom teeth-derived neuronal stem cell (tNSC) cotreatment with granulocyte-colony-stimulating factor (G-CSF) were evaluated for contusion-induced spinal cord injury in rats. Materials & methods:  7 days after contusion, tNSCs were transplanted to the injury site and followed by G-CSF cotreatment for 5 days. Behavioral deficits were evaluated by the Basso, Beattie and Bresnahan test. The injury site was collected for immunohistochemistry analysis. Results: The Basso, Beattie and Bresnahan test significantly improved in the cotreated group compared with the tNSCs or G-CSF single treatment groups. However, inflammation indices did not differ among the three groups. In vitro experiment demonstrated that tNSCs express both G-CSF and its relevant receptor. G-CSF enhanced tNSC proliferation and neurotrophins secretion in vitro . Conclusion: This study demonstrated that G-CSF enhances neurotrophins secretion of tNSCs, and might help improving functional recovery from spinal cord injury in rats if they were given together.
    • Contributed Indexing:
      Keywords: granulocyte-colony-stimulating factor; spinal cord injury; stem cells
    • Accession Number:
      143011-72-7 (Granulocyte Colony-Stimulating Factor)
    • Publication Date:
      Date Created: 20190523 Date Completed: 20200402 Latest Revision: 20200402
    • Publication Date:
      20250114
    • Accession Number:
      10.2217/rme-2018-0104
    • Accession Number:
      31115255