Autoimmunity and Delayed Diagnosis in Pediatric Idiopathic Pulmonary Hemosiderosis.

Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505928 Publication Model: Print Cited Medium: Internet ISSN: 1536-3678 (Electronic) Linking ISSN: 10774114 NLM ISO Abbreviation: J Pediatr Hematol Oncol Subsets: MEDLINE

Publication: 1998- : Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: New York, NY : Raven Press, c1995-

Autoimmune Diseases*/diagnosis ; Autoimmune Diseases*/immunology ; Autoimmune Diseases*/pathology ; Autoimmunity* ; Delayed Diagnosis*; Antibodies, Antineutrophil Cytoplasmic/*immunology; Child ; Hemosiderosis/diagnosis ; Hemosiderosis/immunology ; Hemosiderosis/pathology ; Humans ; Lung Diseases/diagnosis ; Lung Diseases/immunology ; Lung Diseases/pathology ; Macrophages/immunology ; Macrophages/pathology ; Male ; Hemosiderosis, Pulmonary

Idiopathic pulmonary hemosiderosis is characterized by a triad of iron-deficiency anemia, hemoptysis, and radiographic diffuse lung infiltrates. However, the inconsistent initial presentation in children may cause a significant delay in diagnosis. Autoimmune reactivity seems to be the most acceptable theory of pathogenesis. We reported an 8-year-old boy presenting with a cough, fever, and difficulty breathing with a history of iron-deficiency anemia and an abnormal autoimmune response in the last 3 years. Perinuclear antineutrophil cytoplasmic antibodies were positive and chest computed tomography revealed patchy ground glass haziness. Bronchoalveolar lavage fluid showed hemosiderin-laden macrophages. The respiratory symptoms improved with oral corticosteroids.

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0 (Antibodies, Antineutrophil Cytoplasmic)

Date Created: 20190521 Date Completed: 20201103 Latest Revision: 20231213

20231215

10.1097/MPH.0000000000001513

31107369