Association between prediabetes (defined by HbA1 C , fasting plasma glucose, and impaired glucose tolerance) and the development of chronic kidney disease: a 9-year prospective cohort study.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100967793 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2369 (Electronic) Linking ISSN: 14712369 NLM ISO Abbreviation: BMC Nephrol Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, [2000-
    • Subject Terms:
      Glucose Intolerance*/blood ; Glucose Intolerance*/diagnosis ; Glucose Intolerance*/epidemiology ; Prediabetic State*/blood ; Prediabetic State*/epidemiology ; Renal Insufficiency, Chronic*/diagnosis ; Renal Insufficiency, Chronic*/epidemiology; Glycated Hemoglobin/*analysis; Blood Glucose/analysis ; Early Diagnosis ; Female ; Glomerular Filtration Rate ; Humans ; Incidence ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Republic of Korea/epidemiology ; Risk Assessment ; Risk Factors
    • Abstract:
      Background: The aim of the present study was to investigate the clinical impact of prediabetes on the development of incident chronic kidney disease (CKD) in a Korean adult population, using data from the Korea Genome and Epidemiology Study.
      Methods: This prospective cohort study included 7728 Korean adults without baseline CKD and type 2 diabetes. Prediabetes was defined by impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and HbA1 C level. CKD was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m 2 . We assessed the predictive value of prediabetes for the incidence of CKD, and investigated the incidence of cardiovascular disease including coronary artery disease and stroke.
      Results: Over a median follow-up period of 8.7 years, 871 of 7728 (11.3%) subjects developed incident CKD. Patients with prediabetes, as defined by IGT or HbA1 C , developed incident CKD more frequently than the non-prediabetic group did. The risk of CKD development at follow-up was analyzed according to different prediabetes definitions. Compared with the non-prediabetic group, the IGT- (Hazard ratio [HR] = 1.135, 95% confidence interval [CI] = 1.182-1.310, P = 0.043) and HbA1 C -defined prediabetic groups (HR = 1.391, 95% CI = 1.213-1.595, P < 0.001) were significantly associated with incident CKD after adjusting for traditional CKD risk factors; however, IFG was not associated with incident CKD.
      Conclusion: IGT- or HbA1 C -defined prediabetes is an independent predictor of incident CKD. The measurement of these parameters might enable early detection of CKD risk, allowing physicians to initiate preventive measures and improve patient outcomes.
    • References:
      Am J Kidney Dis. 2008 Mar;51(3):373-84. (PMID: 18295053)
      Diabetes Care. 2011 Jul;34(7):1546-51. (PMID: 21593291)
      Nephrol Dial Transplant. 1996 Aug;11(8):1542-6. (PMID: 8856208)
      Age Ageing. 2014 May;43(3):411-7. (PMID: 24321840)
      Clin Exp Nephrol. 2005 Mar;9(1):5-14. (PMID: 15830267)
      Nat Rev Nephrol. 2018 Mar;14(3):151-164. (PMID: 29355169)
      Am J Kidney Dis. 2006 Dec;48(6):926-34. (PMID: 17162147)
      Ann Intern Med. 2009 May 5;150(9):604-12. (PMID: 19414839)
      Lancet. 2012 Jan 14;379(9811):165-80. (PMID: 21840587)
      Kidney Int Suppl (2011). 2013 Dec;3(4):368-371. (PMID: 25019021)
      Diabetes Care. 2003 May;26(5):1333-7. (PMID: 12716784)
      J Am Soc Nephrol. 2006 Jun;17(6):1695-702. (PMID: 16641153)
      Endocr Rev. 2006 May;27(3):242-59. (PMID: 16492903)
      J Am Soc Nephrol. 2000 Feb;11(2):319-29. (PMID: 10665939)
      JAMA. 2004 Jun 2;291(21):2591-9. (PMID: 15173150)
      Lancet. 2017 Mar 25;389(10075):1238-1252. (PMID: 27887750)
      Diabetes Care. 2016 Dec;39(12):2278-2287. (PMID: 27703024)
      Am J Kidney Dis. 2008 Jan;51(1):21-8. (PMID: 18155529)
      J Natl Med Assoc. 2002 Aug;94(8 Suppl):7S-15S. (PMID: 12152917)
      Diabetes Care. 2003 Sep;26(9):2604-8. (PMID: 12941726)
      Am J Kidney Dis. 2009 Jan;53(1):59-69. (PMID: 18838200)
      Nephrol Dial Transplant. 2012 Apr;27(4):1410-5. (PMID: 21908415)
      Diabet Med. 2016 Dec;33(12):1615-1624. (PMID: 26997583)
      World J Diabetes. 2015 Mar 15;6(2):296-303. (PMID: 25789110)
      Prev Med. 2013 Nov;57(5):596-600. (PMID: 23948106)
      Diabetes Care. 2008 Feb;31 Suppl 2:S155-60. (PMID: 18227478)
      Kidney Int. 2015 Dec;88(6):1233-1239. (PMID: 26444029)
      Diabetes Care. 2007 Oct;30(10):2566-8. (PMID: 17626893)
      Clin J Am Soc Nephrol. 2007 Sep;2(5):976-83. (PMID: 17702729)
      Adv Chronic Kidney Dis. 2014 May;21(3):260-6. (PMID: 24780453)
      Diabetes Care. 2005 Oct;28(10):2436-40. (PMID: 16186276)
      Nephrol Dial Transplant. 2012 May;27(5):1821-5. (PMID: 22140135)
      J Ren Nutr. 2015 Mar;25(2):226-9. (PMID: 25511524)
      Korean J Intern Med. 2016 Sep;31(5):920-9. (PMID: 26759157)
    • Contributed Indexing:
      Keywords: Cardiovascular disease; Chronic kidney disease; General population; Prediabetes
    • Accession Number:
      0 (Blood Glucose)
      0 (Glycated Hemoglobin A)
    • Publication Date:
      Date Created: 20190418 Date Completed: 20200423 Latest Revision: 20221207
    • Publication Date:
      20221213
    • Accession Number:
      PMC6469043
    • Accession Number:
      10.1186/s12882-019-1307-0
    • Accession Number:
      30992067