Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation.

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  • Additional Information
    • Source:
      Publisher: Karger Country of Publication: Switzerland NLM ID: 0417373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0399 (Electronic) Linking ISSN: 00421138 NLM ISO Abbreviation: Urol Int Subsets: MEDLINE
    • Publication Information:
      Publication: Basel : Karger
      Original Publication: Basel.
    • Subject Terms:
      Foreskin*; Adrenal Cortex Hormones/*administration & dosage ; Anti-Inflammatory Agents/*therapeutic use ; Genital Diseases, Male/*drug therapy ; Lichen Sclerosus et Atrophicus/*drug therapy ; Mometasone Furoate/*therapeutic use ; Olive Oil/*therapeutic use ; Ozone/*therapeutic use ; Vitamin E/*therapeutic use; Administration, Topical ; Adolescent ; Child ; Child, Preschool ; Humans ; Inflammation/drug therapy ; Male ; Retrospective Studies
    • Abstract:
      Background: Lichen sclerosus (LS) is a disease of the skin of unclear etiology that can occur in the foreskin. Topical therapy with corticosteroids is recommended, but they can have side effects.
      Objectives: We aimed to compare the effects of ozonides with vitamin E acetate (OZOILE) versus topical corticosteroid in children undergoing circumcision.
      Method: Twenty children undergoing circumcision were treated before surgery: 10 children with OZOILE cream and 10 with 0.1% mometasone furoate once a day for 7 days. Ten age-matched patients with LS of the foreskin without any treatment were recruited as controls. Transcript levels of proinflammatory and anti-inflammatory cytokines and e-cadherin were evaluated in removed foreskins by qRT-PCR.
      Results: OZOILE and steroid topical treatment produced a similar reduction of TNF-α and IL-1β mRNA levels in foreskins from patients with LS when compared to untreated patients (p < 0.001). OZOILE and steroid treatment caused an increase in the transcript levels of IL-13 and e-cadherin in the foreskin of patients affected by LS in comparison to untreated foreskin (p < 0.001).
      Conclusions: On the basis of our biochemical data, a randomized clinical trial might be useful to verify the actual clinical effect of OZOILE as alternative treatment to corticosteroids in children affected by LS of the foreskin.
      (© 2019 S. Karger AG, Basel.)
    • Contributed Indexing:
      Keywords: Children; Corticosteroids; Lichen sclerosus; Phimosis; Stable ozonides; Vitamin E acetate
    • Accession Number:
      0 (Adrenal Cortex Hormones)
      0 (Anti-Inflammatory Agents)
      0 (Olive Oil)
      0 (Ozoile)
      04201GDN4R (Mometasone Furoate)
      1406-18-4 (Vitamin E)
      66H7ZZK23N (Ozone)
    • Publication Date:
      Date Created: 20190417 Date Completed: 20200413 Latest Revision: 20200623
    • Publication Date:
      20240829
    • Accession Number:
      10.1159/000499846
    • Accession Number:
      30991399