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Does cognitive dysfunction correlate with neurofilament light polypeptide levels in the CSF of patients with multiple sclerosis?
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- Author(s): Kalatha T;Kalatha T; Arnaoutoglou M; Arnaoutoglou M; Koukoulidis T; Koukoulidis T; Hatzifilippou E; Hatzifilippou E; Bouras E; Bouras E; Baloyannis S; Baloyannis S; Koutsouraki E; Koutsouraki E
- Source:
The Journal of international medical research [J Int Med Res] 2019 May; Vol. 47 (5), pp. 2187-2198. Date of Electronic Publication: 2019 Apr 14.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Sage Publications Country of Publication: England NLM ID: 0346411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-2300 (Electronic) Linking ISSN: 03000605 NLM ISO Abbreviation: J Int Med Res Subsets: MEDLINE
- Publication Information: Publication: Nov. 2012- : London : Sage Publications
Original Publication: Northampton, Eng., Cambridge Medical Publications ltd. - Subject Terms:
- Abstract: Objective: To investigate whether neurofilament light polypeptide (NfL) level in cerebrospinal fluid (CSF), currently a prognostic biomarker of neurodegeneration in patients with multiple sclerosis (MS), may be a potential biomarker of cognitive dysfunction in MS.
Methods: This observational case-control study included patients with MS. CSF levels of NfL were determined using enzyme-linked immunosorbent assay. Cognitive function was measured with the Brief International Cognitive Assessment for MS (BICAMS) battery and Paced Auditory Serial Addition Test (PASAT3), standardized to the Greek population.
Results: Of 39 patients enrolled (aged 42.7 ± 13.6 years), 36% were classified as cognitively impaired according to BICAMS z-scores (-0.34 ± 1.13). Relapsing MS was significantly better than progressive forms regarding BICAMS z-score (mean difference [MD] 1.39; 95% confidence interval [CI] 0.54, 2.24), Symbol Digit Modality Test score (MD 1.73; 95% CI 0.46, 3.0) and Greek Verbal Learning Test (MD 1.77; 95% CI 0.82, 2.72). An inversely proportional association between CSF NfL levels and BICAMS z-scores was found in progressive forms of MS (rp = -0.944).
Conclusions: This study provides preliminary evidence for an association between CSF NfL levels and cognition in progressive forms of MS, which requires validation in larger samples. - References: Ann N Y Acad Sci. 2000 Jun;908:244-54. (PMID: 10911963)
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Prog Nucleic Acid Res Mol Biol. 1998;61:1-23. (PMID: 9752717) - Contributed Indexing: Keywords: BICAMS; Biomarkers; cognitive dysfunction; multiple sclerosis; neurofilament-light
- Accession Number: 0 (Biomarkers)
0 (Neurofilament Proteins)
0 (neurofilament protein L) - Publication Date: Date Created: 20190416 Date Completed: 20191206 Latest Revision: 20200225
- Publication Date: 20240628
- Accession Number: PMC6567748
- Accession Number: 10.1177/0300060519840550
- Accession Number: 30982375
- Source:
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