Scalp bacterial shift in Alopecia areata.

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  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
      Alopecia Areata/*microbiology ; Dysbiosis/*microbiology ; Scalp/*microbiology; Adult ; Alopecia Areata/complications ; Case-Control Studies ; DNA, Bacterial/genetics ; DNA, Bacterial/isolation & purification ; Dysbiosis/complications ; Female ; Humans ; Male ; Microbiota/genetics ; Middle Aged ; Propionibacterium/isolation & purification ; Staphylococcus aureus/isolation & purification ; Staphylococcus epidermidis/isolation & purification ; Young Adult
    • Abstract:
      The role of microbial dysbiosis in scalp disease has been recently hypothesized. However, little information is available with regards to the association between microbial population on the scalp and hair diseases related to hair growth. Here we investigated bacterial communities in healthy and Alopecia areata (AA) subjects. The analysis of bacterial distribution at the genus level highlighted an increase of Propionibacterium in AA subjects alongside a general decrease of Staphylococcus. Analysis of log Relative abundance of main bacterial species inhabiting the scalp showed a significant increase of Propionibacterium acnes in AA subjects compared to control ones. AA scalp condition is also associated with a significant decrease of Staphylococcus epidermidis relative abundance. No significant changes were found for Staphylococcus aureus. Therefore, data from sequencing profiling of the bacterial population strongly support a different microbial composition of the different area surrounded hair follicle from the epidermis to hypodermis, highlighting differences between normal and AA affected the scalp. Our results highlight, for the first time, the presence of a microbial shift on the scalp of patients suffering from AA and gives the basis for a larger and more complete study of microbial population involvement in hair disorders.
      Competing Interests: DP, BM are employed by Giuliani S.p.A.; FR serves as consultant for Giuliani S.p.A; GG is part of Board of Directors of Giuliani S.p.A. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
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    • Accession Number:
      0 (DNA, Bacterial)
    • Publication Date:
      Date Created: 20190412 Date Completed: 20200129 Latest Revision: 20200309
    • Publication Date:
      20221213
    • Accession Number:
      PMC6459526
    • Accession Number:
      10.1371/journal.pone.0215206
    • Accession Number:
      30973913