Prevalence of Achilles tendon xanthoma and familial hypercholesterolemia in patients with coronary artery disease undergoing percutaneous coronary intervention.

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  • Additional Information
    • Source:
      Publisher: Springer Verlag Country of Publication: Japan NLM ID: 8511258 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-2573 (Electronic) Linking ISSN: 09108327 NLM ISO Abbreviation: Heart Vessels Subsets: MEDLINE
    • Publication Information:
      Publication: Tokyo : Springer Verlag
      Original Publication: Tokyo ; Secaucus, NY : Springer International, c1985-
    • Subject Terms:
      Percutaneous Coronary Intervention*; Achilles Tendon/*diagnostic imaging ; Coronary Artery Disease/*complications ; Hyperlipoproteinemia Type II/*epidemiology ; Xanthomatosis/*epidemiology; Aged ; Cholesterol, LDL/blood ; Coronary Artery Disease/blood ; Coronary Artery Disease/surgery ; Female ; Humans ; Hyperlipoproteinemia Type II/blood ; Japan/epidemiology ; Male ; Middle Aged ; X-Rays ; Xanthomatosis/diagnostic imaging
    • Abstract:
      Familial hypercholesterolemia (FH) is reportedly associated with the development of coronary artery disease (CAD), especially acute coronary syndrome (ACS). However, the prevalence of FH in patients with stable CAD is still unclear. The aim of this study was to investigate the prevalence of Achilles tendon xanthoma (ATX) and heterozygous FH in patients with stable CAD and ACS undergoing percutaneous coronary intervention (PCI). A total of 423 patients with CAD (273 stable CAD and 150 ACS) undergoing PCI at Chiba University Hospital between June 2016 and February 2018 were enrolled in this study. Soft X-ray radiography of the Achilles tendon was performed in all patients, and a maximum thickness of 9 mm or more is regarded as ATX. Heterozygous FH was diagnosed according to the Japan Atherosclerosis Society Guidelines. In comparisons between stable CAD and ACS patients, ATX was observed in 9.2% vs. 15.3% (p = 0.055), and heterozygous FH was diagnosed in 3.7% vs. 5.3% (p = 0.416), respectively. Among ACS patients, those with ST elevation myocardial infarction (STEMI) showed the highest prevalence of ATX (19.5%) and FH (7.3%). Whereas ATX and heterozygous FH were considerably observed in patients with ACS, a certain number of ATX and heterozygous FH were also detected in stable CAD patients.
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    • Contributed Indexing:
      Keywords: Achilles tendon xanthoma; Coronary artery disease; Familial hypercholesterolemia
    • Accession Number:
      0 (Cholesterol, LDL)
    • Publication Date:
      Date Created: 20190411 Date Completed: 20200225 Latest Revision: 20200225
    • Publication Date:
      20240829
    • Accession Number:
      10.1007/s00380-019-01400-6
    • Accession Number:
      30968218