Primary oral leiomyosarcoma: A systematic review and update.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Ko E;Ko E
  • Source:
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2019 Oct; Vol. 48 (9), pp. 780-787. Date of Electronic Publication: 2019 Apr 25.
  • Publication Type:
    Journal Article; Systematic Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 8911934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0714 (Electronic) Linking ISSN: 09042512 NLM ISO Abbreviation: J Oral Pathol Med Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford, UK : Wiley-Blackwell
      Original Publication: Copenhagen : Munksgaard, c1989-
    • Subject Terms:
      Leiomyosarcoma*; Humans ; Radiography ; Survival Rate
    • Abstract:
      The aim of this systematic review was to address the clinicopathologic inconsistencies noted with primary oral leiomyosarcoma in the literature by amassing the available data published into a comprehensive analysis. Eligibility criteria included publications of cases with dedicated immunohistochemical work-up along with radiographs to evaluate location. Based on these criteria, the systematic review compiled 29 cases. Four primary location sites were identified in the reported cases: soft tissue presentation only, soft tissue with bony involvement, bony involvement only, and bony involvement with a soft tissue component. The majority of primary oral leiomyosarcoma cases reviewed showed a soft tissue predilection, which is in contrast to prior reports of jawbones being the most common site. In addition, there was an improved 5-year survival rate for primary oral leiomyosarcoma limited to the oral cavity and gnathic bones without extension into paranasal sinuses.
      (© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
    • References:
      Solar AA, Jordan RCK. Soft tissue tumors and common metastases of the oral cavity. Periodontol 2000. 2011;57(1):177-197.
      Castaldi A, Arcuri T, Carta M, et al. Primary leiomyosarcoma of the oral tongue: magnetic resonance and ultrasonography findings with histopathologic correlation. Acta Radiol Stockh Swed 1987. 2006;47(5):514-517.
      Carter LC, Aguirre A, Boyd B, et al. Primary leiomyosarcoma of the mandible in a 7-year-old girl: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;87(4):477-484.
      Lo ML, Favia G, Farronato G, et al. Primary gingival leiomyosarcoma. A clinicopathological study of 1 case with prolonged survival. J Clin Periodontol. 2002;29(2):182-187.
      Yang S-W, Chen T-M, Tsai C-Y, et al. A peculiar site of leiomyosarcoma: the tongue tip-report of a case. Int J Oral Maxillofac Surg. 2006;35(5):469-471.
      Montgomery E, Goldblum JR, Fisher C. Leiomyosarcoma of the head and neck: a clinicopathological study. Histopathology. 2002;40(6):518-525.
      Nikitakis NG, Lopes MA, Bailey JS, et al. Oral leiomyosarcoma: review of the literature and report of two cases with assessment of the prognostic and diagnostic significance of immunohistochemical and molecular markers. Oral Oncol. 2002;38(2):201-208.
      Ethunandan M, Stokes C, Higgins B, et al. Primary oral leiomyosarcoma: a clinico-pathologic study and analysis of prognostic factors. Int J Oral Maxillofac Surg. 2007;36(5):409-416.
      Dry SM, Jorgensen JL, Fletcher CD. Leiomyosarcomas of the oral cavity: an unusual topographic subset easily mistaken for nonmesenchymal tumours. Histopathology. 2000;36(3):210-220.
      Lo Muzio L, Favia G, Mignogna MD, et al. Primary intraoral leiomyosarcoma of the tongue: an immunohistochemical study and review of the literature. Oral Oncol. 2000;36(6):519-524.
      Rege IC, Costa NL, Batista AC, et al. High-grade primary leiomyosarcoma in the mandible: diagnosis and treatment. Head Neck. 2013;35(2):E44-E48.
      Divyambika CV, Sathasivasubramanian S, Krithika CL, et al. Pediatric oral leiomyosarcoma: rare case report. J Cancer Res Ther. 2012;8(2):282-285.
      Rodini CO, Pontes FSC, Pontes HAR, et al. Oral leiomyosarcomas: report of two cases with immunohistochemical profile. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104(4):e50-e55.
      Mesquita RA, Migliari DA, de Sousa SO, et al. Leiomyosarcoma of the buccal mucosa: a case report. J Oral Maxillofac Surg. 1998;56(4):504-507.
      Gupta R, Astekar M, Dandriyal R, et al. Leiomyosarcoma of maxilla: a case report with review of literature. J Exp Ther Oncol. 2017;11(2):147-153.
      Moghadam SA, Khodayari A, Mokhtari S. Primary leiomyosarcoma of the mandible. J Oral Maxillofac Pathol. 2014;18(2):308-311.
      Kenea TT, Kebede BA, Gozjuze FM, et al. Primary leiomyosarcoma of the mandibular alveolar mucosa of a 12-year-old child from Ethiopia: a case report. Craniomaxillofac Trauma Reconstr. 2017;10(1):56-59.
      Santana MVM, Duarte ECB, Johann ACBR, et al. Ulcerated midline nodule of the hard palate. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105(4):412-416.
      Mendonça EF, Martins dSC, Meneghini AJ, et al. Low-grade gingival leiomyosarcoma in a child. J Dent Child (Chic). 2008;75(3):301-305.
      Cheng C-Y, Chang K-M, Chang K-W, et al. Rapidly growing mass in mandibular gingiva. J Oral Maxillofac Surg. 2004;62(2):214-217.
      Suarez-Alen F, Otero-Rey E, Penamaria-Mallon M, et al. Oral leiomyosarcoma: the importance of early diagnosis. Gerodontology. 2015;32(4):314-317.
      Nagpal DKJ, Prabhu PR, Shah A, et al. Leimyosarcoma of the buccal mucosa and review of literature. J Oral Maxillofac Pathol. 2013;17(1):149.
      Ahn JH, Mirza T, Ameerally P. Leiomyosarcoma of the tongue with multiple metastases: a case report and review of literature. J Oral Maxillofac Surg. 2012;70(7):1745-1750.
      Yadav R, Bharathan S. Leiomyosarcoma of the buccal mucosa: a case report with immunohistochemistry findings. J Oral Sci. 2008;50(2):215-218.
      Crossman T, Ward P, Herold J. Leiomyosarcoma of the tongue: a case report. Br J Oral Maxillofac Surg. 2008;46(8):e69-e70.
      Mayall F, Hickman J, Bulman C, et al. Leiomyosarcoma of the tongue: a very rare tumour. J Laryngol Otol. 1994;108(7):617-618.
      Goldschmidt PR, Goldschmidt JD, Lieblich SE, et al. Leiomyosarcoma presenting as a mandibular gingival swelling: a case report. J Periodontol. 1999;70(1):84-89.
      Karlis V, Zaslow M, Minkowitz G, et al. Leiomyosarcoma of the mandible: report of a case and literature review. J Oral Maxillofac Surg. 1996;54(9):1127-1130.
      Patel K, French C, Khariwala SS, et al. Intraosseous leiomyosarcoma of the mandible: a case report. J Oral Maxillofac Surg. 2013;71(7):1209-1216.
      Pinheiro J, Alves S, Okuda E, et al. Primary leiomyosarcoma of the mandible. A case report. Med Oral Patol Oral Cirugia Bucal 2007;12(1):E56-E59.
      Vilos GA, Rapidis AD, Lagogiannis GD, et al. Leiomyosarcomas of the oral tissues: clinicopathologic analysis of 50 cases. J Oral Maxillofac Surg. 2005;63(10):1461-1477.
      Laccourreye O, Cauchois R, Laccourreye L, et al. Primary leiomyosarcoma of the mandible. Am J Otolaryngol. 1996;17(6):415-419.
      Eppsteiner RW, DeYoung BR, Milhem MM, et al. Leiomyosarcoma of the head and neck: a population-based analysis. Arch Otolaryngol Head Neck Surg. 2011;137(9):921-924.
      Antonescu CR, Erlandson RA, Huvos AG. Primary leiomyosarcoma of bone: a clinicopathologic, immunohistochemical, and ultrastructural study of 33 patients and a literature review. Am J Surg Pathol. 1997;21(11):1281-1294.
      Riaz N, Warriach RA, Aftab A. Massive leiomyosarcoma of the maxilla. J Ayub Med Coll Abbottabad. 2011;23(2):180-183.
      Mizutani H, Tohnai I, Yambe M, et al. Leiomyosarcoma of the maxillary gingiva: a case report. Nagoya J Med Sci. 1995;58(3-4):165-170.
      Nishi M, Mimura T, Senba I. Leiomyosarcoma of the maxilla. J Oral Maxillofac Surg. 1987;45(1):64-68.
      de Bree R, van der Waal I, de Bree E, et al. Management of adult soft tissue sarcomas of the head and neck. Oral Oncol. 2010;46(11):786-790.
      Chang AE, Chai X, Pollack SM, et al. Analysis of clinical prognostic factors for adult patients with head and neck sarcomas. Otolaryngol Head Neck Surg. 2014;151(6):976-983.
      Sandhu SV, Sodhi SPS, Rai S, et al. Primary leiomyosarcoma of the maxilla: an investigative loom-report of a challenging case and review of literature. J Oral Maxillofac Pathol. 2014;18(3):453-459.
      Wada S, Yue L, Furuta I, et al. Leiomyosarcoma in the maxilla: a case report. Int J Oral Maxillofac Surg. 2002;31(2):219-221.
      Savastano G, Palombini L, Muscariello V, et al. Leiomyosarcoma of the maxilla: a case report. J Oral Maxillofac Surg. 1998;56(9):1101-1103.
      Izumi K, Maeda T, Cheng J, et al. Primary leiomyosarcoma of the maxilla with regional lymph node metastasis. Report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;80(3):310-319.
    • Contributed Indexing:
      Keywords: leiomyosarcoma; oral cavity; oral medicine; oral pathology
    • Publication Date:
      Date Created: 20190409 Date Completed: 20200109 Latest Revision: 20200109
    • Publication Date:
      20240829
    • Accession Number:
      10.1111/jop.12858
    • Accession Number:
      30958581